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Molecular Mechanisms of Human Parturition

Special Issue Editor

Special Issue Information

Dear Colleagues,

The systems that control the onset and progress of labor are important in understanding the steps involved in birth.

The Special Issue will include manuscripts from contributors containing text that describes various mechanisms regulating uterine contractility and cervical changes leading to the initiation and progress of term and preterm labor and birth. Mechanisms involved in labor and birth pertain to: hormones, drugs to augment or suppress contractility, mechanical and electrical systems that control myometrial contractility, interactions of various uterine control systems, and the regulation of the cervix during labor and birth.

Prof. Dr. Robert Garfield
Guest Editor

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Keywords

  • pregnancy
  • parturition
  • birth
  • uterine contractions
  • cervix
  • pharmacological interventions in birthing

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Published Papers (2 papers)

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Research

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14 pages, 2066 KiB  
Article
The Beneficial Effects of Prenatal Biotin Supplementation in a Rat Model of Intrauterine Caloric Restriction to Prevent Cardiometabolic Risk in Adult Female Offspring
by Asdrubal Aguilera-Méndez, Ian Figueroa-Fierros, Xóchilt Ruiz-Pérez, Daniel Godínez-Hernández, Alfredo Saavedra-Molina, Patricia Rios-Chavez, Santiago Villafaña, Daniel Boone-Villa, Daniel Ortega-Cuellar, Marcia Yvette Gauthereau-Torres, Renato Nieto-Aguilar and Zoraya Palomera-Sanchez
Int. J. Mol. Sci. 2024, 25(16), 9052; https://doi.org/10.3390/ijms25169052 - 21 Aug 2024
Viewed by 1047
Abstract
Numerous studies indicate that intrauterine growth restriction (IUGR) can predispose individuals to metabolic syndrome (MetS) in adulthood. Several reports have demonstrated that pharmacological concentrations of biotin have therapeutic effects on MetS. The present study investigated the beneficial effects of prenatal biotin supplementation in [...] Read more.
Numerous studies indicate that intrauterine growth restriction (IUGR) can predispose individuals to metabolic syndrome (MetS) in adulthood. Several reports have demonstrated that pharmacological concentrations of biotin have therapeutic effects on MetS. The present study investigated the beneficial effects of prenatal biotin supplementation in a rat model of intrauterine caloric restriction to prevent cardiometabolic risk in adult female offspring fed fructose after weaning. Female rats were exposed to a control (C) diet or global caloric restriction (20%) (GCR), with biotin (GCRB) supplementation (2 mg/kg) during pregnancy. Female offspring were exposed to 20% fructose (F) in drinking water for 16 weeks after weaning (C, C/F, GCR/F, and GCRB/F). The study assessed various metabolic parameters including Lee’s index, body weight, feed conversion ratio, caloric intake, glucose tolerance, insulin resistance, lipid profile, hepatic triglycerides, blood pressure, and arterial vasoconstriction. Results showed that GCR and GCRB dams had reduced weights compared to C dams. Offspring of GCRB/F and GCR/F dams had lower body weight and Lee’s index than C/F offspring. Maternal biotin supplementation in the GCRB/F group significantly mitigated the adverse effects of fructose intake, including hypertriglyceridemia, hypercholesterolemia, hepatic steatosis, glucose and insulin resistance, hypertension, and arterial hyperresponsiveness. This study concludes that prenatal biotin supplementation can protect against cardiometabolic risk in adult female offspring exposed to postnatal fructose, highlighting its potential therapeutic benefits. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Human Parturition)
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Review

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22 pages, 414 KiB  
Review
MicroRNA Associations with Preterm Labor—A Systematic Review
by Adrianna Kondracka, Aleksandra Stupak, Magda Rybak-Krzyszkowska, Bartosz Kondracki, Anna Oniszczuk and Anna Kwaśniewska
Int. J. Mol. Sci. 2024, 25(7), 3755; https://doi.org/10.3390/ijms25073755 - 28 Mar 2024
Viewed by 1596
Abstract
This systematic review delves into the connections between microRNAs and preterm labor, with a focus on identifying diagnostic and prognostic markers for this crucial pregnancy complication. Covering studies disseminated from 2018 to 2023, the review integrates discoveries from diverse pregnancy-related scenarios, encompassing gestational [...] Read more.
This systematic review delves into the connections between microRNAs and preterm labor, with a focus on identifying diagnostic and prognostic markers for this crucial pregnancy complication. Covering studies disseminated from 2018 to 2023, the review integrates discoveries from diverse pregnancy-related scenarios, encompassing gestational diabetes, hypertensive disorders and pregnancy loss. Through meticulous search strategies and rigorous quality assessments, 47 relevant studies were incorporated. The synthesis highlights the transformative potential of microRNAs as valuable diagnostic tools, offering promising avenues for early intervention. Notably, specific miRNAs demonstrate robust predictive capabilities. In conclusion, this comprehensive analysis lays the foundation for subsequent research, intervention strategies and improved outcomes in the realm of preterm labor. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Human Parturition)
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