Role of Mitochondria in Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 May 2025 | Viewed by 1509
Special Issue Editors
Interests: p53; tumor suppressor; phase-separation; droplets; membrane-less organelles; cardiolipin metabolism; mitochondrial quality control; apoptosis; cancer metabolism
Interests: mitochondria; lysosome; drug resistance; cancer stem; glioblastoma; translation; ferroptosis; cancer metabolism
Special Issue Information
Dear Colleagues,
In healthy cells, mitochondria are essential for producing ATP efficiently via respiration, but in pathological situations, they may trigger apoptosis by releasing cytochrome c; thus, they serve critical functions in both cell survival and death. Mitochondria are also central to cellular metabolism. Nearly 100 years ago, Otto Warburg opined, “The mitochondria of cancer cells are abnormal”. He observed that cancer cells predominantly depend on glycolytic energy production, even though they exist in aerobic conditions. Since then, a number of studies have reported mitochondrial dysregulation and dysfunction in cancer cells. However, how and why these abnormal mitochondria contribute to cancer initiation and progression is not entirely clear. This Special Issue seeks to clarify the full picture of mitochondria in cancer. For this purpose, we invite both original and review articles on cancer mitochondria from perspectives of mitochondrial DNA/RNA, proteins, metabolism, apoptosis, oxidative stress, proteostasis, autophagy, lipid, fission and fusion, and droplets. This Special Issue also welcomes both basic and translational research on molecular bases and pathophysiology of cancer mitochondria, and therapeutic and diagnostic applications of dysfunctional mitochondria in cancer.
Prof. Dr. Hirofumi Arakawa
Prof. Dr. Takeshi Uchiumi
Dr. Manabu Futamura
Guest Editors
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Keywords
- metabolism
- apoptosis
- fusion and fission
- mitochondrial DNA
- mitochondrial RNA
- mitochondrial proteins
- mitophagy
- lipid
- cardiolipin
- phase separation
- oxidative phosphorylation
- proteostasis
- mitochondrial quality control
- TFAM
- anti-cancer drug
- imaging
- cancer therapy
- cancer diagnosis
- Warburg effect
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