DNA Damage, Oxidative Stress and Metabolism in Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 1394
Special Issue Editors
Interests: DNA damage; DNA repair; oncometabolites; oxidative damage; iron nanoparticles; genotoxicity
Interests: hypoxia; oncometabolites; cancer; metastasis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer-associated metabolic alterations caused by intratumoral hypoxia or gene mutations result in the abnormal accumulation of small intermediates of metabolism with oncogenic properties. The over-production of these so-called oncometabolites is emerging as a new mechanism of dysregulation of the DNA damage response through their effects on chromatin structure. These oncometabolites remodel chromatin structure by acting on the methylation of DNA and histones. This results in increased DNA damage and repression of DNA-repair pathways. In normal cells, then, accumulation of these metabolites triggers cell transformation and tumor development, whereas in tumor cells, the inhibition of DNA-repair pathways may contribute to a better response to cancer therapy.
With this in mind, this Special Issue will include research articles and reviews related to the crosstalk between DNA damage, oxidative stress and metabolism in cancer, for example:
- DNA damage signaling, oxidative stress and cellular metabolism.
- Impact of cancer-associated metabolic alterations on nuclear DNA damage and oxidative stress signaling pathways.
- Linkage between chemotherapy-induced DNA damage, oxidative stress and metabolism.
Dr. Luisa María Sierra
Dr. María Dolores Chiara Romero
Guest Editors
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Keywords
- DNA damage
- oncometabolites
- hypoxia
- DNA repair
- oxidative stress
- chromatin remodeling
- DNA methylation
- homologous recombination repair
- ALKB proteins
- fumarate hydratase
- methylguanine DNA methyl transferase gene silencing
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