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The Impact of Natural Bioactive Compounds on Human Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 970

Special Issue Editor


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Guest Editor
1. Department of Oriental Medicine and Biotechnology, Kyung Hee University, Yongin 17104, Republic of Korea
2. BioMedical Research Institute, Kyung Hee University, Yongin 17104, Republic of Korea
Interests: natural product chemistry; nuclear magnetic resonance; structural elucidation; molecular networking; metabolomics; medicinal herb; HPLC; LC/MS; GC/MS
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Special Issue Information

Dear Colleagues,

Since ancient times, and owing to their efficacy due to their secondary metabolites, natural products, especially plants, have been consumed primarily as foods but also as cosmetics and medicines. Across numerous previous studies, the efficacy of numerous natural products has been revealed according to their major components and various medicines, such as paclitaxel, aspirin, artemisin, and oseltamivir, have been developed. Since new diseases, such as monkeypox and SARS-CoV-2, continue to emerge, the demand for these drugs will continue to increase. Therefore, this Special Issue of the International Journal of Molecular Science will focus on the structural elucidation of active components from natural products for the treatment of disease. Furthermore, this Special Issue will include a broad range of basic and translational articles, both original research reports and reviews, focused on the latest developments in medicines based on natural products and the compounds derived from natural products.

Dr. Yeong-geun Lee
Guest Editor

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Keywords

  • natural product chemistry
  • nuclear magnetic resonance
  • structural elucidation
  • herbal drug

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Published Papers (1 paper)

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15 pages, 2300 KiB  
Article
Vitexin Mitigates Haloperidol-Induced Orofacial Dyskinesia in Rats through Activation of the Nrf2 Pathway
by Shu-Mei Chen, Mao-Hsien Wang, Kuo-Chi Chang, Chih-Hsiang Fang, Yi-Wen Lin and Hsiang-Chien Tseng
Int. J. Mol. Sci. 2024, 25(18), 10206; https://doi.org/10.3390/ijms251810206 - 23 Sep 2024
Viewed by 637
Abstract
Vitexin (VTX), a C-glycosylated flavone found in various medicinal herbs, is known for its antioxidant, anti-inflammatory, and neuroprotective properties. This study investigated the protective effects of VTX against orofacial dyskinesia (OD) in rats, induced by haloperidol (HPD), along with the neuroprotective mechanisms underlying [...] Read more.
Vitexin (VTX), a C-glycosylated flavone found in various medicinal herbs, is known for its antioxidant, anti-inflammatory, and neuroprotective properties. This study investigated the protective effects of VTX against orofacial dyskinesia (OD) in rats, induced by haloperidol (HPD), along with the neuroprotective mechanisms underlying these effects. OD was induced by administering HPD (1 mg/kg i.p.) to rats for 21 days, which led to an increase in the frequency of vacuous chewing movements (VCMs) and tongue protrusion (TP). VTX (10 and 30 mg/kg) was given intraperitoneally 60 min after each HPD injection during the same period. On the 21st day, following assessments of OD, the rats were sacrificed, and nitrosative and oxidative stress, antioxidant capacity, mitochondrial function, neuroinflammation, and apoptosis markers in the striatum were measured. HPD effectively induced OD, while VTX significantly reduced HPD-induced OD, decreased oxidative stress, enhanced antioxidant capacity, prevented mitochondrial dysfunction, and reduced neuroinflammatory and apoptotic markers in the striatum, and the protective effects of VTX on both behavioral and biochemical aspects of HPD-induced OD were significantly reduced when trigonelline (TGN), an inhibitor of the nuclear factor erythroid-2-related factor 2 (Nrf2)-mediated pathway, was administered. These findings suggest that VTX provides neuroprotection against HPD-induced OD, potentially through the Nrf2 pathway, indicating its potential as a therapeutic candidate for the prevention or treatment of tardive dyskinesia (TD) in clinical settings. However, further detailed research is required to confirm these preclinical findings and fully elucidate VTX’s therapeutic potential in human studies. Full article
(This article belongs to the Special Issue The Impact of Natural Bioactive Compounds on Human Health and Disease)
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