Genome Structure, Function and Dynamic Regulation of Cell Fate
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 20 May 2025 | Viewed by 913
Special Issue Editors
Interests: bioinformatics; biophysics; medical technology
Interests: genom-architecture on the micro- and nano-scale during tumor genesis and after ionizing radiation exposure; nano-probes for DNA; DNA patterning; protein arrangements on the nano-scale in cell membranes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The cell nucleus is a complex system in which simultaneous reactions and functions take place to keep the cell as a well-running individualized, specialized system. The cell nucleus contains chromatin packed in various degrees of density and separated into sub-volumes of territories and sub-chromosomal domains. Between the chromatin, there is enough “free” space for floating RNA, proteins, enzymes, ATPs, ions, water molecules, etc., which are trafficked either actively (using ATP energy) or passively by super- and supra-diffusion to the interaction points where they are required. It seems that this trafficking works somehow automatically and drives the system perfectly. So, genome organization and structure seem to be in an “entanglement” with genome function and molecular dynamics. This “landscape” of genome structure, function, and dynamics represents an advancement in biophysical, biological, and biomedical research. Recent advancements in molecular biology have, on the one hand, revolutionized our understanding of how genetic information is encoded and dynamically regulated. On the other hand, biophysical research has shown that epigenetic pathways impact chromatin organization and vice versa. These complex interactions govern cell function and cell fate decisions. This Special Issue aims to gather cutting-edge research that explores the latest developments in this exciting field. Topics of interest for this Special Issue include, but are not limited to, experimental and theoretical investigations of molecular mechanisms underlying chromatin remodeling, epigenetic regulation, DNA damage response, and transcriptional control in relation to their impact on cellular development, differentiation, and (re)programming or, in general, on cell fate. We invite submissions from researchers across the globe to contribute to this vibrant discussion and propel this field forward.
Prof. Dr. Georg Hildenbrand
Prof. Dr. Michael Hausmann
Guest Editors
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Keywords
- genome structure and organization
- DNA sequence patterning and functional genomics
- epigenetic regulation and chromatin remodeling
- DNA damage response and cellular developments
- cellular differentiation and cell fate
- transcriptional control
- chromatin architecture
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