The Role of Extracellular Matrix in Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 June 2025 | Viewed by 630
Special Issue Editor
Interests: tumor angiogenesis; vessel co-option; lung metastases; tissue fibrosis; pericytes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The extracellular matrix (ECM) is a structure that surrounds and provides support to the cells in the body’s tissues and is mainly composed of proteins and polysaccharides. It plays a key role in the development and physiology of tissues. In tumors, the ECM plays a crucial role in their progression and response to therapy. Additionally, the extracellular matrix undergoes numerous changes during tumor development and anti-tumor treatments. Numerous anti-tumor therapeutic strategies have been based on different aspects of extracellular matrix remodeling: inhibition of collagen synthesis, ECM degradation, or the reduction in its stiffness. This Special Issue aims to address the cellular and molecular changes experienced by the ECM in tumors and metastasis, as well as the therapeutic strategies aimed at modifying the matrix for tumor treatment.
Dr. José M. Muñoz-Félix
Guest Editor
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Keywords
- extracellular matrix
- cancer
- collagen
- integrins
- metastasis
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