Anti-Inflammatory and Metabolic Effects of G Protein-Coupled Receptor Signaling
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 28 March 2025 | Viewed by 162
Special Issue Editor
Interests: inflammation; cytokine network; sirtuins; endothelial signaling; human placenta; stem cells; pathophysiology of diabetes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
G protein-coupled receptors (GPCRs) are the largest family of metabotropic receptors, constituting eukaryotes’ largest and most diverse group of membrane receptors. Despite distinguishing five structurally distinct subfamilies (glutamate, rhodopsin, adhesion, frizzled/taste2, and secretin) within the GPCRs superfamily, these integral membrane proteins contain invariably an extracellular amino terminus, seven transmembrane (7TM) α-helical domains, and an intracellular carboxy terminus. Among the nearly 800 GPCRs encoded in the human genome, those associated with signaling pathways influence the inflammatory response and metabolism.
The anti-inflammatory and metabolic effects of signaling through GPCRs are of understandable interest due to their potential therapeutic possibilities, including in frequently occurring metabolic diseases accompanied by inflammation, such as overweight/obesity, atherosclerosis, type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD).
This Special Issue is dedicated to all aspects of GPCR signaling, including physiological and pathologic conditions with direct or indirect anti-inflammatory and metabolic effects.
When considering your submission, please remember that IJMS is a journal of molecular science. However, submissions of clinical studies that include biomolecular experiments or pathological research with case sample data are welcomed.
Prof. Dr. Dariusz Szukiewicz
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- G protein-coupled receptors (GPCRs)
- seven transmembrane domain (7TM) receptors
- metabotropic receptors
- membrane receptors
- GPCRs signaling
- GPCRs signaling pathways
- anti-inflammatory effects
- inflammatory diseases
- metabolic diseases
- metabolic effects
- anti-inflammatory treatment
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
