Yeasts: Model Systems for Molecular Research
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 20 May 2025 | Viewed by 958
Special Issue Editor
Interests: Saccharomyces cerevisiae; Schizosaccharomyces pombe; yeast; genome stability; DNA repair; telomeres
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The baker’s yeast (Saccharomyces cerevisiae) and the fission yeast (Schizosaccharomyces pombe) are two widely used and popular organisms due to their facilitation in dissecting complex and basic biological processes. Indeed, state-of-the-art genetic, biochemical, molecular biological and genomic tools have been developed for these organisms. This allows researchers to rapidly carry out sophisticated genetic screening, genomic manipulations and biochemical dissections with ease. Since more than half of the yeast proteins have a human ortholog, it is also possible to learn, by using yeast systems, about the properties and regulations of mammalian systems.
Moreover, yeasts have been proven to be very convenient for genetic engineering, synthetic biology, biotechnology projects and heterologous gene expression. A plethora of techniques and plasmids, as well as mutant and fusion libraries, allow for easy manipulation and engineering of these organisms. Sometimes, additional yeast species such as members of the Komagataella (formerly known as Pichia), Candida, Kluyveromyces and other clades are used for particular projects.
The genome of the yeast Saccharomyces cerevisiae was the first eukaryotic genome to be sequenced, and gene knockout collections exist for both organisms. Numerous yeast databases make it easy to find up-to-date information about them; the most popular database for S. cerevisiae can be found at https://www.yeastgenome.org/. Similarly, the S. pombe research community has collaborated to make all data related to fission yeast available at https://www.pombase.org/.
Yeasts are widely used to analyze the genes of any other eukaryotic organism and to study genes associated with human diseases. The yeast two-hybrid system is commonly used to probe potential physical interactions between proteins. Many plasmids and yeast strains are commercially available, including sets of different deletion strains.
The main aim of this Special Issue is to highlight the advantages of yeasts as model organisms in which to dissect molecular mechanisms. We encourage the submission of research articles or short communications presenting results that advance our understanding of genetic regulation, protein interactions, biochemical pathway dissection or new biotechnological relevant techniques. Reviews and mini-reviews on various aspects of yeast molecular biology are also welcome.
Prof. Dr. Martin Kupiec
Guest Editor
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Keywords
- yeasts as a model organism
- yeast genomics
- DNA replication and repair
- cell cycle and its regulation
- transcription
- translation and posttranslational modification
- signal transduction
- chromosomal biology
- nuclear import and export
- mitochondria
- synthetic biology
- yeast biotechnology
- biomedicine
- in lab evolution
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