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Antimicrobial, Anti-Biofilm and Anti-Virulence Activities of Novel Compounds

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 1731

Special Issue Editors


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Guest Editor
Department of Pharmacy, University “G. d’Annunzio” Chieti-Pescara, 66100 Chieti, Italy
Interests: antimicrobial, anti-biofilm and anti-virulence activities of bioactive substances of natural origin; semi-synthesis and innovative biomaterials; the research activity has concerned oral cavity microorganisms
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmacy, University “G. d’Annunzio” Chieti-Pescara, 66100 Chieti, Italy
Interests: antimicrobial; anti-biofilm and anti-virulence activities of natural compounds alone and combined with antibiotics against multi drug-resistant strains (Helicobacter pylori, Staphylococcus spp., Pseudomonas aeruginosa, Candida albicans, Mycobacterium abscessus and other fast-growing mycobacteria)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The global prevalence of antibiotic-resistant bacteria has become a very significant concern. Natural products are increasingly investigated as they possess a large array of chemical compounds capable of exhibiting several biological activities such as potent antibacterial and antimicrobial properties.

Natural products also have the capability to affect distinct stages of biofilm formation, such as adhesion, motility, EPS maturation and targeting, as well as microbial virulence factors.

Natural compounds from plants, microbes and animals must be investigated to uncover their full potential as valuable sources to tackle persistent microbial infection.

The aim of this Special Issue is to collect important contributions in the field of natural and synthetic compounds via the investigation of novel antimicrobial, anti-biofilm and anti-virulence activities.

Research areas may include, but not limited to, the following:

  • Study of natural compounds against microorganisms and ones that are multidrug-resistant;
  • Study of anti-biofilm and anti-virulence activities of natural and/or semisynthetic/ synthetic products;
  • Study of combinations of natural compounds and conventional antibiotics/antimicrobials;
  • Study of an innovative delivery system to improve the bioavailability of natural compounds.

In this Special Issue, original research articles and reviews are welcome. I look forward to receiving your contributions.

Dr. Mara Di Giulio
Dr. Silvia Di Lodovico
Guest Editors

Manuscript Submission Information

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Keywords

  • antimicrobial natural compound
  • resistant strains
  • mono- and polymicrobial biofilm
  • synergisms
  • antivirulence natural compounds

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Published Papers (1 paper)

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Research

19 pages, 3781 KiB  
Article
Endophytic Penicillium oxalicum AUMC 14898 from Opuntia ficus-indica: A Novel Source of Tannic Acid Inhibiting Virulence and Quorum Sensing of Extensively Drug-Resistant Pseudomonas aeruginosa
by Hoda S. Nouh, Nessma A. El-Zawawy, Mohamed Halawa, Ebrahim M. Shalamesh, Sameh Samir Ali, Grażyna Korbecka-Glinka, Awad Y. Shala and Shimaa El-Sapagh
Int. J. Mol. Sci. 2024, 25(20), 11115; https://doi.org/10.3390/ijms252011115 - 16 Oct 2024
Viewed by 1074
Abstract
Pseudomonas aeruginosa is a harmful pathogen that causes a variety of acute and chronic infections through quorum sensing (QS) mechanisms. The increasing resistance of this bacterium to numerous antibiotics has created a demand for new medications that specifically target QS. Endophytes can be [...] Read more.
Pseudomonas aeruginosa is a harmful pathogen that causes a variety of acute and chronic infections through quorum sensing (QS) mechanisms. The increasing resistance of this bacterium to numerous antibiotics has created a demand for new medications that specifically target QS. Endophytes can be the source of compounds with antibacterial properties. This research is the first to examine tannic acid (TA) produced by endophytic fungus as a potential biotherapeutic agent. A novel endophytic fungal isolate identified as Penicillium oxalicum was derived from the cladodes of Opuntia ficus-indica (L.). The species identification for this isolate was confirmed through sequencing of the internal transcribed spacer region. The metabolites from the culture of this isolate were extracted using ethyl acetate, then separated and characterized using chromatographic methods. This led to the acquisition of TA, a compound that shows strong anti-QS and excellent antibacterial effects against extensively drug-resistant P. aeruginosa strains. Furthermore, it was shown that treating P. aeruginosa with the obtained TA reduced the secretion of virulence factors controlled by QS in a dose-dependent manner, indicating that TA inhibited the QS characteristics of P. aeruginosa. Simultaneously, TA significantly inhibited the expression of genes associated with QS, including rhlR/I, lasR/I, and pqsR. In addition, in silico virtual molecular docking showed that TA could efficiently bind to QS receptor proteins. Our results showed that P. oxalicum could be a new source of TA for the treatment of infections caused by extensively drug-resistant P. aeruginosa. Full article
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