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Molecular Biology of Tumor Cells: Present and Future

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 1301

Special Issue Editor


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Guest Editor
Department for Histology and Embryology, Medical University of Warsaw, Chalubinskiego 5, 02-004 Warsaw, Poland
Interests: cancer biology

Special Issue Information

Dear Colleagues,

This Special Issue will focus on the molecular biology of tumor cells. Malignant disease is a worldwide problem involving patients, their families, medical professionals, and health systems.

At the moment, we offer numerous therapies including surgery, radiation, chemotherapy, derivatives of classical therapeutics and biological drugs and many other strategies that defend against cancer cells, like miRNA, CRISPR and immune system-based drugs. Biological drugs—especially those that target de-regulated signaling cascades—can maintain long-lasting disease-free periods. Without basic studies of cancer cells on the molecular biology level, the above-mentioned progress will not be possible. Because tumor malignant cells change gradually and gain some resistant phenotypes, the further development of cancer-related studies on the molecular biology level may result in the development of knowledge through which more targeted and less harmful therapy can be offered to patients.

This Special Issue intends to showcase the current progress related to molecular biology research on tumor cells. Original research articles, review articles and short communications within (but not restricted to) the described research fields are welcome.

Dr. Izabela Mlynarczuk-Bialy
Guest Editor

Manuscript Submission Information

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Keywords

  • molecular immunology of cancer
  • ubiquitin-proteasome system in cancer
  • microRNA in cancer
  • extracellular matrix in cancer
  • metalloproteinases
  • cancer stem cells
  • ROS
  • molecular prognosis and diagnosis of cancer
  • cancer epigenetics

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Published Papers (1 paper)

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Review

29 pages, 1782 KiB  
Review
Different Strategies to Overcome Resistance to Proteasome Inhibitors—A Summary 20 Years after Their Introduction
by Paweł Tyrna, Grzegorz Procyk, Łukasz Szeleszczuk and Izabela Młynarczuk-Biały
Int. J. Mol. Sci. 2024, 25(16), 8949; https://doi.org/10.3390/ijms25168949 - 16 Aug 2024
Viewed by 938
Abstract
Proteasome inhibitors (PIs), bortezomib, carfilzomib, and ixazomib, are the first-line treatment for multiple myeloma (MM). They inhibit cytosolic protein degradation in cells, which leads to the accumulation of misfolded and malfunctioned proteins in the cytosol and endoplasmic reticulum, resulting in cell death. Despite [...] Read more.
Proteasome inhibitors (PIs), bortezomib, carfilzomib, and ixazomib, are the first-line treatment for multiple myeloma (MM). They inhibit cytosolic protein degradation in cells, which leads to the accumulation of misfolded and malfunctioned proteins in the cytosol and endoplasmic reticulum, resulting in cell death. Despite being a breakthrough in MM therapy, malignant cells develop resistance to PIs via different mechanisms. Understanding these mechanisms drives research toward new anticancer agents to overcome PI resistance. In this review, we summarize the mechanism of action of PIs and how MM cells adapt to these drugs to develop resistance. Finally, we explore these mechanisms to present strategies to interfere with PI resistance. The strategies include new inhibitors of the ubiquitin–proteasome system, drug efflux inhibitors, autophagy disruption, targeting stress response mechanisms, affecting survival and cell cycle regulators, bone marrow microenvironment modulation, and immunotherapy. We list potential pharmacological targets examined in in vitro, in vivo, and clinical studies. Some of these strategies have already provided clinicians with new anti-MM medications, such as panobinostat and selinexor. We hope that further exploration of the subject will broaden the range of therapeutic options and improve patient outcomes. Full article
(This article belongs to the Special Issue Molecular Biology of Tumor Cells: Present and Future)
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