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Molecular Research Progress of Skin and Skin Diseases: 2nd Edition

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Guest Editor
Department of Dermatology, Seoul St. Mary’s Hospital, College of Medicine College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea
Interests: atopic dermatitis; psoriasis; inflammatory; skin disease
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Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue, “Molecular Research Progress of Skin and Skin Diseases”, published in 2023–2024.

Skin diseases, including skin cancer and inflammatory skin conditions such as atopic dermatitis, psoriasis, hair loss, and acne, are among the most chronic and difficult-to-treat conditions which constantly challenge dermatologists. Refractory patients always have an unmet need for innovative and effective new treatments. With advances in evidence-based molecular research, these therapies are being developed and are actively being investigated in clinical trials. Therefore, this Special Issue, titled “Molecular Research Progress of Skin and Skin Diseases”, aims to highlight the molecular biological advances that are currently being made in the treatment of skin and skin diseases and their use in patient care. In this issue, we welcome papers that focus on emerging pathogenic mechanisms in skin disease research, reviewing them, and exploring the promise of therapeutics targeting them. We hope to provide new inspiration for better understanding skin and skin diseases and for better treating them.

Dr. Ji Hyun Lee
Guest Editor

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Keywords

  • atopic dermatitis
  • psoriasis
  • alopecia
  • vitiligo
  • acne
  • skin cancer
  • JAK-STAT
  • inflammatory skin disease

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Published Papers (1 paper)

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Research

19 pages, 3061 KiB  
Article
Association of Genetic Polymorphisms in SLC45A2, TYR, HERC2, and SLC24A in African Women with Melasma: A Pilot Study
by Nomakhosi Mpofana, Zinhle Pretty Mlambo, Mokgadi Ursula Makgobole, Ncoza Cordelia Dlova and Thajasvarie Naicker
Int. J. Mol. Sci. 2025, 26(3), 1158; https://doi.org/10.3390/ijms26031158 - 29 Jan 2025
Viewed by 288
Abstract
Melasma is a chronic skin disorder characterized by hyperpigmentation, predominantly affecting women with darker skin types, including those of African descent. This study investigates the association between genetic variants in SLC45A2, TYR, HERC2, and SLC24A5 genes and the severity of [...] Read more.
Melasma is a chronic skin disorder characterized by hyperpigmentation, predominantly affecting women with darker skin types, including those of African descent. This study investigates the association between genetic variants in SLC45A2, TYR, HERC2, and SLC24A5 genes and the severity of melasma in women of reproductive age. Forty participants were divided into two groups: twenty with facial melasma and twenty without. Deoxyribonucleic acid (DNA) was extracted from blood samples and genotyped using TaqMan assays to identify allele frequencies and genotype distributions. Significant associations were observed for the TYR gene (rs1042602), HERC2 gene (rs1129038), and SLC24A5 gene (rs1426654) polymorphisms, highlighting their potential roles in melasma susceptibility. For example, the rs1042602 Single Nucleotide Polymorphisms (SNP) in the TYR gene showed a strong association with melasma, with the AA genotype conferring a markedly increased risk. Similarly, the rs1129038 SNP in the HERC2 gene and the rs1426654 SNP in the SLC24A5 gene revealed significant genetic variations between groups in women of African descent. These findings underscore the influence of genetic polymorphisms on melasma’s pathogenesis, emphasizing the need for personalized approaches to its treatment, particularly for women with darker skin types. Full article
(This article belongs to the Special Issue Molecular Research Progress of Skin and Skin Diseases: 2nd Edition)
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