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Molecular Immunology of Liver Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 2383

Special Issue Editor


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Guest Editor
Pharmaceutical Sciences Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Skaggs School, Aurora, CO 80045, USA
Interests: inflammatory liver diseases; complement; innate immunity; macrophages; type 3 cytokines; tissue fibrosis; steatotic liver disease

Special Issue Information

Dear Colleagues,

Chronic liver disease is a leading cause of mortality worldwide and non-resolving inflammation is critical driver of disease progression. While inflammation, occurring from the innate and adaptive immune system, precedes clinical manifestation of liver disease, there remain no therapeutic options for outside of liver transplant. In this special issue entitled "Molecular Immunology of Liver Diseases" in the International Journal of Molecular Sciences, we seek submissions filling gaps in knowledge that aim to uncover mechanisms related to immune dysregulation throughout the spectrum of liver disease, including steatosis, steatohepatitis, and liver fibrosis. This collection of original papers and reviews will seek to redefine the processes that govern inflammatory responses as well gain a better understanding how we can direct future studies to address increasing rates of chronic inflammatory liver disease world-wide. Submissions are encouraged to mechanistic in nature in areas of immunometabolism, organ-organ crosstalk (e.g., gut-liver, adipose-liver), oxidative eustress and/or distress, cellular signaling, transcriptional regulation and cytokine/chemokine networks.

Dr. Rebecca McCullough
Guest Editor

Manuscript Submission Information

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Keywords

  • steatotic liver disease
  • metabolic-associated liver disease
  • alcohol-associated liver disease
  • inflammation
  • innate immunity
  • adaptive immunity
  • liver fibrosis
  • biomarker discovery

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Published Papers (1 paper)

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Review

20 pages, 1494 KiB  
Review
The Impact of Liver Failure on the Immune System
by Alicja Dąbrowska, Bartosz Wilczyński, Jakub Mastalerz, Julia Kucharczyk, Julita Kulbacka, Anna Szewczyk and Nina Rembiałkowska
Int. J. Mol. Sci. 2024, 25(17), 9522; https://doi.org/10.3390/ijms25179522 - 1 Sep 2024
Viewed by 2087
Abstract
Liver failure profoundly affects the immune system, leading to dysregulation of innate and adaptive immune response. This review explores the intricate relationship between liver function and immune homeostasis. The role of the liver as a central hub in immune response initiation is elucidated, [...] Read more.
Liver failure profoundly affects the immune system, leading to dysregulation of innate and adaptive immune response. This review explores the intricate relationship between liver function and immune homeostasis. The role of the liver as a central hub in immune response initiation is elucidated, emphasizing its involvement in hepatic inflammation induction and subsequent systemic inflammation. Cytokines, chemokines, growth factors, and lipid mediators orchestrate these immune processes, serving as both prognostic biomarkers and potential therapeutic targets in liver failure-associated immune dysregulation, which might result from acute-on-chronic liver failure (ACLF) and cirrhosis. Furthermore, the review delves into the mechanisms underlying immunosuppression in liver failure, encompassing alterations in innate immune cell functions such as neutrophils, macrophages, and natural killer cells (NK cells), as well as perturbations in adaptive immune responses mediated by B and T cells. Conclusion: Understanding the immunological consequences of liver failure is crucial for developing targeted therapeutic interventions and improving patient outcomes in liver disease management. Full article
(This article belongs to the Special Issue Molecular Immunology of Liver Diseases)
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