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Extracellular Vesicles (EVs) in Cancer Progression and Metastasis: Molecular Insights and Clinical Outlook

Special Issue Editor


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Guest Editor
Department of Life, Health, and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
Interests: extracellular vesicles; malignant tumors; anti-inflammatory; anti-fibrosis

Special Issue Information

Dear Colleagues,

Extracellular vesicles (EVs) are cell-derived particles that integrate with physiological processes in all life forms, having been identified in prokaryotes, animals, and plants. They encompass molecules that exert crucial biological effects in cell-to-cell communication and cell homeostasis. Notably, EVs play a critical role in cancer progression and metastasis.

This Special Issue, entitled "Extracellular Vesicles (EVs) in Cancer Progression and Metastasis: Molecular Insights and Clinical Outlook", aims to cover a selection of recent research topics and current review articles in the field of EVs in cancer. Our focus will be on the pro/anti-oncogenic, pro/anti-angiogenic, and pro/anti-metastatic functions mediated by EVs, whether secreted by cancer cells or by the metastatic and primary tumor microenvironment. We warmly encourage article submissions on the effects of bacterial- and plant-derived EVs on tumor physiology, as well as on the topic of the theranostic potential of EVs as tools for precision medicine in cancer. Adherence to MISEV2023 guidelines will be considered a strong plus for original articles.

Dr. Alfredo Cappariello
Guest Editor

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Keywords

  • mammalian extracellular vesicles
  • plant-derived extracellular vesicles
  • bacterial-derived extracellular vesicles
  • cancer progression
  • cell migration and invasion
  • tumor microenvironment
  • epithelial-to-mesenchymal transition (EMT)
  • drug delivery
  • diagnostics
  • precision medicine

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Published Papers (1 paper)

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Review

30 pages, 2460 KiB  
Review
Recent Advances of Small Extracellular Vesicles for the Regulation and Function of Cancer-Associated Fibroblasts
by Chengdong Liang, Maoye Wang, Yongli Huang, Judy Wai Ping Yam, Xu Zhang and Xiaoxin Zhang
Int. J. Mol. Sci. 2024, 25(23), 12548; https://doi.org/10.3390/ijms252312548 - 22 Nov 2024
Abstract
Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population in the tumor microenvironment (TME) that critically affect cancer progression. Small extracellular vesicles (sEVs) act as information messengers by transmitting a wide spectrum of biological molecules, including proteins, nucleic acids, and metabolites, from donor cells [...] Read more.
Cancer-associated fibroblasts (CAFs) are a heterogeneous cell population in the tumor microenvironment (TME) that critically affect cancer progression. Small extracellular vesicles (sEVs) act as information messengers by transmitting a wide spectrum of biological molecules, including proteins, nucleic acids, and metabolites, from donor cells to recipient cells. Previous studies have demonstrated that CAFs play important roles in tumor progression by regulating tumor cell proliferation, metastasis, therapeutic resistance, and metabolism via sEVs. In turn, tumor-derived sEVs can also regulate the activation and phenotype switch of CAFs. The dynamic crosstalk between CAFs and cancer cells via sEVs could ultimately determine cancer progression. In this review, we summarized the recent advance of the biological roles and underlying mechanisms of sEVs in mediating CAF-tumor cell interaction and its impact on cancer progression. We also reviewed the clinical applications of tumor- and CAF-derived sEVs, which could identify novel potential targets and biomarkers for cancer diagnosis, therapy, and prognosis. Full article
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