Neuroinflammation and Cellular Senescence in Brain Aging and Neurodegeneration: From Molecular Mechanisms to Therapeutic Applications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 63
Special Issue Editors
Interests: pathophysiology; inflammation; cell biology; toxicology; neurodegeneration; COPD; aging and age-related disorders
Special Issues, Collections and Topics in MDPI journals
2. Institut de Recerca en Nutrició i Seguretat Alimentària (INSA), Universitat de Barcelona (UB), Av. Prat de la Riva 171, 08921 Santa Coloma de Gramanet, Spain
Interests: nutraceuticals; functional foods; polyphenols; pentacyclic triterpenes; bioavailability; LC-MS; colon cancer; inflammation; toxicology; aging and age-related disorders
Special Issue Information
Dear Colleagues,
The complex interplay between neuroinflammation and cellular senescence represents a crucial axis in the pathogenesis of neurodegenerative disorders. This Special Issue aims to compile cutting-edge research exploring the molecular and cellular mechanisms that connect these processes to neurodegeneration, while also highlighting innovative therapeutic approaches.
We welcome contributions investigating the role of neuroinflammation-induced DNA damage, mitochondrial dysfunction, and protein aggregation in promoting cellular senescence within the central nervous system. Of particular interest are studies examining how senescent cells, through their senescence-associated secretory phenotype (SASP), modify the brain microenvironment and influence neighboring cells, including neurons, astrocytes, microglia, and oligodendrocytes.
This Special Issue will cover research on blood–brain barrier integrity, neurovascular unit dysfunction, and the influence of peripheral inflammation on central nervous system homeostasis. We encourage submissions exploring novel biomarkers for early detection of neuroinflammation and senescence, as well as innovative therapeutic strategies such as senolytic compounds, anti-inflammatory agents, cell-based therapies, and targeted drug delivery systems. Articles investigating the impact of lifestyle factors—including diet, exercise, and stress on neuroinflammation and cellular senescence—are also welcome.
The integration of various research approaches, from molecular biology and biochemistry to advanced imaging techniques, -omics technologies, and artificial intelligence-driven drug discovery platforms, will provide a comprehensive understanding of these interconnected processes.
Dr. Jordi Olloquequi
Dr. M. Emília Juan
Guest Editors
Manuscript Submission Information
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Keywords
- SASP
- glial activation
- age-related disorders
- neurotherapeutics
- molecular signaling
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