Pharmacological Treatment of Neuroinflammation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 May 2025 | Viewed by 945
Special Issue Editor
Special Issue Information
Dear Colleagues,
Neuroinflammation is a critical pathophysiological process that plays a central role in the development and progression of neurodegenerative diseases (NDDs). Several studies have suggested that in NDDs (including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis), inflammation is not only a result of neurodegeneration but also a crucial player in this process. In the central nervous system, effectors of inflammatory response are immune cell systems as well as glial cells and, mainly, microglia cells. Particularly, microglia act as sensors for disturbed brain tissue homeostasis and accumulate locally in response to neuronal cell injury or foreign entry in the brain. The differential activation of microglia is the central point that regulates neuroinflammation, and it can result in neurotoxicity or neuroprotection.
Based on these considerations, the therapeutic modulation of glial activation and consequent neuroinflammation could represent valid candidates for the treatment or prevention of common NDDs.
Dr. Beatrice Polini
Guest Editor
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Keywords
- microglia
- neuroinflammation
- neurodegeneration
- Alzheimer’s disease
- Parkinson’s disease
- therapeutic
- natural molecules
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