Atherosclerosis: The Impact of Dysfunctional Lipid Homeostasis and Inflammation on the Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 6646
Special Issue Editor
Interests: inflammation; cytokines; cell signaling; atherosclerosis; macrophages; foam cells; nutraceuticals; gene expression
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Atherosclerosis, an inflammatory disorder of the vasculature and the underlying cause of cardiovascular diseases such as myocardial infarction and cerebrovascular accidents, is responsible for almost a third of all global deaths. Atherosclerosis is initiated by endothelial cell disfunction by various risk factors that then results in a series of changes, including recruitment of immune cells such as monocytes and their differentiation into macrophages, transformation of macrophages into foam cells, death of such foam cells leading to the formation of lipid-rich necrotic core, chronic inflammation via activation of inflammasome and production of pro-inflammatory cytokines, proliferation and migration of smooth muscle cells from the media to the intima to form plaque stabilizing fibrous cap, and plaque rupture resulting in thrombosis and clinical complications of the disease. Current therapies against atherosclerosis are not fully effective and associated with various side effects. Studies aimed at further advancing our understanding of the molecular basis of the disease, particularly the roles of different disease-associated genes and factors together with the molecular mechanisms underlying their actions along with the impact of dysfunctional lipid homeostasis and inflammation on the disease and therapeutic avenues that target them are therefore required.
This Special Issue is focused on atherosclerosis and will include original articles and reviews on mechanism-based in vitro and in vivo together with human studies aimed at advancing our understanding of the molecular basis of atherosclerosis with focus on the impact of dysfunctional lipid homeostasis and inflammation on the disease together with therapeutic approaches that target them. Potential topics include, but are not limited to, molecular biology of atherosclerosis with mechanistic insights from cell culture and animal model systems together with human subjects addressing aspects such as cellular responses, signal transduction, gene expression, gene function, intracellular targets, lipid and lipoprotein metabolism, biomarkers, preventative and therapeutic approaches, and several others.
Prof. Dr. Dipak Ramji
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- atherosclerosis
- cardiovascular disease
- inflammation
- cytokines
- lipid metabolism
- lipoproteins
- gene expression
- gene function
- cellular processes
- model systems
- mechanisms
- signaling
- prevention
- treatment
- biomarkers
- co-morbiditie
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
