Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.1
4.9
Journals
IJMS
Special Issues
Molecular Insights into Metabolic Pathways and Age-Related Pathologies
ijms-logo
Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Molecular Insights into Metabolic Pathways and Age-Related Pathologies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (20 December 2024) | Viewed by 3309

Special Issue Editors

Dr. Arianna Vignini

E-Mail Website
Guest Editor
Department of Clinical Sciences, Università Politecnica delle Marche, 60100 Ancona, Italy
Interests: oxidative and nitrosative stress; bioactive compunds; NCDs; ageing; taste recognition
Special Issues, Collections and Topics in MDPI journals
Dr. Monia Cecati

E-Mail Website
Guest Editor
Department of Clinical Sciences, Polytechnic University of Marche, 60020 Ancona, Italy
Interests: dysregulated metabolic pathways; cancer; inflammation; epigenetic modifications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The World Health Organization defines a person as elderly when she/he is 65 years of age or above. In 2020, more than 147 million people worldwide were between the ages of 80 and 99, accounting for 1.9% of the world's population. The increased life expectancy in industrialized countries has unfortunately also led to a significant increase in the incidence of age-related diseases (ARDs), including cardiovascular diseases, cancer and neurodegenerative disorders. Senescent cells are characterized by the presence of specific phenotype known as senescence-associated secretory phenotype (SASP) due to synthesis and release of matrix-degrading molecules and pro-inflammatory mediators. SASP contributes to the establishment and maintenance of low-grade inflammation (“inflammaging”) which promotes the major ASDs inducing changes in the metabolic pathways responsible for cellular homeostasis. Intensive research activity defined several hallmarks of aging including genomic instability, telomere shortening, epigenetic alterations, loss of proteostasis, deregulating nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion and altered intercellular communication. In this Special Issue, we invite authors to submit original research and review articles investigating different metabolic changes leading to ASDs and associated therapeutic approaches. Also, we gratefully appreciate all the contributions focused on the identifications of novel biomarkers useful for the diagnosis and prognosis of ARDs.

Dr. Arianna Vignini
Dr. Monia Cecati
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aging
  • age-associated diseases
  • dysregulated metabolic pathways
  • inflammation
  • biomarkers
  • therapeutics

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review, Other

15 pages, 6951 KiB  
Article
A Senescent Cluster in Aged Human Hematopoietic Stem Cell Compartment as Target for Senotherapy
by Laura Poisa-Beiro, Jonathan J. M. Landry, Bowen Yan, Michael Kardorff, Volker Eckstein, Laura Villacorta, Peter H. Krammer, Judith Zaugg, Anne-Claude Gavin, Vladimir Benes, Daohong Zhou, Simon Raffel and Anthony D. Ho
Int. J. Mol. Sci. 2025, 26(2), 787; https://doi.org/10.3390/ijms26020787 - 17 Jan 2025
Viewed by 558
Abstract
To identify the differences between aged and young human hematopoiesis, we performed a direct comparison of aged and young human hematopoietic stem and progenitor cells (HSPCs). Alterations in transcriptome profiles upon aging between humans and mice were then compared. Human specimens consist of [...] Read more.
To identify the differences between aged and young human hematopoiesis, we performed a direct comparison of aged and young human hematopoietic stem and progenitor cells (HSPCs). Alterations in transcriptome profiles upon aging between humans and mice were then compared. Human specimens consist of CD34+ cells from bone marrow, and mouse specimens of hematopoietic stem cells (HSCs; Lin− Kit+ Sca1+ CD150+). Single-cell transcriptomic studies, functional clustering, and developmental trajectory analyses were performed. A significant increase in multipotent progenitor 2A (MPP2A) cluster is found in the early HSC trajectory in old human subjects. This cluster is enriched in senescence signatures (increased telomere attrition, DNA damage, activation of P53 pathway). In mouse models, the accumulation of an analogous subset was confirmed in the aged LT-HSC population. Elimination of this subset has been shown to rejuvenate hematopoiesis in mice. A significant activation of the P53–P21WAF1/CIP1 pathway was found in the MPP2A population in humans. In contrast, the senescent HSCs in mice are characterized by activation of the p16Ink4a pathway. Aging in the human HSC compartment is mainly caused by the clonal evolution and accumulation of a senescent cell cluster. A population with a similar senescence signature in the aged LT-HSCs was confirmed in the murine aging model. Clearance of this senescent population with senotherapy in humans is feasible and potentially beneficial. Full article
(This article belongs to the Special Issue Molecular Insights into Metabolic Pathways and Age-Related Pathologies)
►▼ Show Figures

Figure 1

Review

Jump to: Research, Other

26 pages, 662 KiB  
Review
Preeclampsia as a Study Model for Aging: The Klotho Gene Paradigm
by Monia Cecati, Stefania Fumarola, Salvatore Vaiasicca, Laura Cianfruglia, Arianna Vignini, Stefano Raffaele Giannubilo, Monica Emanuelli and Andrea Ciavattini
Int. J. Mol. Sci. 2025, 26(3), 902; https://doi.org/10.3390/ijms26030902 - 22 Jan 2025
Viewed by 354
Abstract
Aging and pregnancy are often considered opposites in a woman’s biological timeline. Aging is defined by a gradual decline in the functional capabilities of an organism over its lifetime, while pregnancy is characterized by the presence of the transient placenta, which fosters the [...] Read more.
Aging and pregnancy are often considered opposites in a woman’s biological timeline. Aging is defined by a gradual decline in the functional capabilities of an organism over its lifetime, while pregnancy is characterized by the presence of the transient placenta, which fosters the cellular fitness necessary to support fetal growth. However, in the context of preeclampsia, pregnancy and aging share common hallmarks, including clinical complications, altered cellular phenotypes, and heightened oxidative stress. Furthermore, women with pregnancies complicated by preeclampsia tend to experience age-related disorders earlier than those with healthy pregnancies. Klotho, a gene discovered fortuitously in 1997 by researchers studying aging mechanisms, is primarily expressed in the kidneys but also to a lesser extent in several other tissues, including the placenta. The Klotho protein is a membrane-bound protein that, upon cleavage by ADAM10/17, is released into the circulation as soluble Klotho (sKlotho) where it plays a role in modulating oxidative stress. This review focuses on the involvement of sKlotho in the development of preeclampsia and age-related disorders, as well as the expression of the recently discovered Mytho gene, which has been associated with skeletal muscle atrophy. Full article
(This article belongs to the Special Issue Molecular Insights into Metabolic Pathways and Age-Related Pathologies)
►▼ Show Figures

Figure 1

Other

Jump to: Research, Review

13 pages, 907 KiB  
Case Report
Possible Role of Tauroursodeoxycholic Acid (TUDCA) and Antibiotic Administration in Modulating Human Gut Microbiota in Home Enteral Nutrition Therapy for the Elderly: A Case Report
by Emanuele Francini, Paolo Orlandoni, Debora Sparvoli, Nikolina Jukic Peladic, Maurizio Cardelli, Rina Recchioni, Stefania Silvi, Vilberto Stocchi, Sabrina Donati Zeppa, Antonio Domenico Procopio, Maria Capalbo, Fabrizia Lattanzio, Fabiola Olivieri and Francesca Marchegiani
Int. J. Mol. Sci. 2024, 25(13), 7115; https://doi.org/10.3390/ijms25137115 - 28 Jun 2024
Viewed by 1683
Abstract
Tauroursodeoxycholic acid (TUDCA) increases the influx of primary bile acids into the gut. Results obtained on animal models suggested that Firmicutes and Proteobacteria phyla are more resistant to bile acids in rats. As part of a pilot study investigating the role of probiotics [...] Read more.
Tauroursodeoxycholic acid (TUDCA) increases the influx of primary bile acids into the gut. Results obtained on animal models suggested that Firmicutes and Proteobacteria phyla are more resistant to bile acids in rats. As part of a pilot study investigating the role of probiotics supplementation in elderly people with home enteral nutrition (HEN), a case of a 92-year-old woman with HEN is reported in the present study. She lives in a nursing home and suffers from Alzheimer’s disease (AD); the patient had been prescribed TUDCA for lithiasis cholangitis. The aim of this case report is therefore to investigate whether long-term TUDCA administration may play a role in altering the patient’s gut microbiota (GM) and the impact of an antibiotic therapy on the diversity of microbial species. Using next generation sequencing (NGS) analysis of the bacterial 16S ribosomal RNA (rRNA) gene a dominant shift toward Firmicutes and a remodeling in Proteobacteria abundance was observed in the woman’s gut microbiota. Considering the patient’s age, health status and type of diet, we would have expected to find a GM with a prevalence of Bacteroidetes phylum. This represents the first study investigating the possible TUDCA’s effect on human GM. Full article
(This article belongs to the Special Issue Molecular Insights into Metabolic Pathways and Age-Related Pathologies)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop