The Role of Choroid Plexus in Neurological Health
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 March 2025 | Viewed by 228
Special Issue Editor
Interests: circadian rhythm; blood-cerebrospinal fluid barrier; drug delivery; chronotherapy
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Special Issue Information
Dear Colleagues,
The choroid plexus forms an important physiological barrier, the blood–cerebrospinal fluid barrier, which physically separates the blood from the cerebrospinal fluid. Several neuroprotective roles are attributed to the choroid plexus. Cerebrospinal fluid secretion, which in its majority is assured by the choroid plexus, is important for neurological function by delivering some molecules like hormones and trophic factors to the brain. These molecules can be bloodborne or directly secreted into the cerebrospinal fluid by the choroid plexus. In addition, the choroid plexus prevents the passage of noxious compounds to the brain due to the presence of efflux transporters and tight junctions between epithelial cells. The choroid plexus also participates in the removal of brain waste metabolites and is an important regulator of the immune cell movement between blood and cerebrospinal fluid. The improper function of the choroid plexus transport system and secretory activity, as well as the impairment of barrier capabilities, are associated with disease states. This highlights the importance of exploring the role of the choroid plexus in neurological health.
This Special Issue aims to increase knowledge of how choroid plexus physiology impacts normal brain functioning. Reviews, original articles, and short communications that cover the topics of how the choroid plexus influences a disease state and how a disease state influences the choroid plexus physiology, as well as the impact of choroid plexus dysfunction on disease progression, are welcome in this Special Issue. In the International Journal of Molecular Sciences, molecules are the object of study.
Dr. Telma Quintela
Guest Editor
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Keywords
- choroid plexus
- cerebrospinal fluid
- neurological health
- blood–CSF barrier
- central nervous system
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