Mitochondrial Function and Dynamics during Malignant Transformation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 30 May 2025 | Viewed by 1089
Special Issue Editor
Interests: cancer metabolism; breast cancer; colorectal cancer; metabolomic; mitochondria; OXPHOS; glycolysis; metabolic plasticity
Special Issue Information
Dear Colleagues,
One of the hallmarks of cancer is its ability to reprogram the metabolism to support the proliferation and metastatic activity of malignant cells. In cancer cells, mitochondria are integrated with specialized phosphotransfer circuits that distribute energy from the mitochondria to the intracellular compartments of ATP consumption sites. Phosphotransfer circuits for the delivery of ATP are composed of creatine kinase, adenylate kinase, nucleoside diphosphate kinases, and glycolytic/glucogenolytic enzymes, which act alongside associated mitochondrial substrate shuttles such as glycerol-3-phosphate dehydrogenase/glycerol kinase. The mitochondria have a key role in the AMP signaling via the AK→ AMP→ AMPK pathway; they serve to control the cell cycle and proliferation of cancer cells. A high level of intracellular ATP will support malignant transformation and drive the formation of an aggressive cancer cell phenotype. Increased ATP production via the mitochondria increases the cell proliferation, stemness, anchorage independence, migration, invasion, metastasis, antioxidant capacity, and drug resistance of cancer cells. In cancer cells, the mitochondria move with cells to areas of high energetic need in order to support the migration of cancer cells. For this Special Issue, we invite the submission of manuscripts (both reviews and articles) that detail how OXPHOS interacts with glycolysis; we hope to provide new insights into the metabolic plasticity of cancer cells.
Dr. Aleksandr Klepinin
Guest Editor
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Keywords
- AMPK
- phosphotransfer network
- mitochondria
- cancer metabolism
- glycolysis
- metabolic plasticity
- cancer cell migration
- molecular oncology
- cancer treatment strategy
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