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Self-Assembled Protein-, Polymer-, and Surfactant-Based Nanostructured Materials and Their Potential Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: closed (20 November 2024) | Viewed by 1500

Special Issue Editor

Special Issue Information

Dear Colleagues,

Self-assembled protein-, polymer- and surfactant-based nanostructured materials are systems with one or more dimensions or features reduced to the nanoscale, presenting some unique and unprecedented physicochemical properties. The possibility of manipulating and regulating these properties makes them suitable for a large variety of pharmaceutical, cosmetic, agricultural and other industrial applications. The variety of morphologies and functions that can be engineered for the creation of bio-inspired materials that can replicate biological activity has been greatly enhanced with the insertion of functional groups within the nanostructured units. The self-assembly of nanomaterials continues to be a focal point of current research at the intersection of materials science and engineering, biotechnology and nanomedicine. By fusing the ideas of supramolecular, physical and colloid chemistry, it will stimulate the interest of biologists, physicists and materials engineers, and can lead to the development of sustainable industrial applications.

The aim of this Special Issue is to bring together original and high-quality research papers covering the most recent advances, as well as comprehensive reviews addressing state-of-the-art topics in the field of the self-assembled and nanostructured materials and their potential applications.

In advance, I would like to gratefully acknowledge the authors and reviewers who will participate in the elaboration of this Special Issue and who will contribute to the development of research based on the topic of protein-, polymer- and surfactant-based nanostructured materials and their potential applications.

Dr. Ádám Juhász
Guest Editor

Manuscript Submission Information

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Keywords

  • self-assembly
  • bioinspired
  • biomimetics
  • nanostructures
  • protein
  • polymer
  • surfactant

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Published Papers (1 paper)

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Research

10 pages, 4117 KiB  
Article
Supramolecular Nanoparticles of Histone and Hyaluronic Acid for Co-Delivery of siRNA and Photosensitizer In Vitro
by Minxing Hu, Jianwei Bao, Yuanmei Zhang, Lele Wang, Ya Zhang, Jiaxin Zhang, Jihui Tang and Qianli Zou
Int. J. Mol. Sci. 2024, 25(10), 5424; https://doi.org/10.3390/ijms25105424 - 16 May 2024
Cited by 1 | Viewed by 1156
Abstract
Small interfering RNA (siRNA) has significant potential as a treatment for cancer by targeting specific genes or molecular pathways involved in cancer development and progression. The addition of siRNA to other therapeutic strategies, like photodynamic therapy (PDT), can enhance the anticancer effects, providing [...] Read more.
Small interfering RNA (siRNA) has significant potential as a treatment for cancer by targeting specific genes or molecular pathways involved in cancer development and progression. The addition of siRNA to other therapeutic strategies, like photodynamic therapy (PDT), can enhance the anticancer effects, providing synergistic benefits. Nevertheless, the effective delivery of siRNA into target cells remains an obstacle in cancer therapy. Herein, supramolecular nanoparticles were fabricated via the co-assembly of natural histone and hyaluronic acid for the co-delivery of HMGB1-siRNA and the photosensitizer chlorin e6 (Ce6) into the MCF-7 cell. The produced siRNA-Ce6 nanoparticles (siRNA-Ce6 NPs) have a spherical morphology and exhibit uniform distribution. In vitro experiments demonstrate that the siRNA-Ce6 NPs display good biocompatibility, enhanced cellular uptake, and improved cytotoxicity. These outcomes indicate that the nanoparticles constructed by the co-assembly of histone and hyaluronic acid hold enormous promise as a means of siRNA and photosensitizer co-delivery towards synergetic therapy. Full article
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