Impact of Endogenic and Exogenic Oxidative Stress Triggers on Pregnant Woman, Fetus, and Child, 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 20 June 2025 | Viewed by 2828
Special Issue Editor
2. Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000 Ljubljana, Slovenia
Interests: pregnancy complications; screening for Down syndrome; autism spectrum disorders; tumor markers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In all living organisms, there is a delicate balance between oxidation caused by reactive species (RS, also called free radicals) and antioxidant defense. A shift in this balance is the cause of a condition known as “oxidative stress” (OS), which can cause cellular damage that eventually leads to premature aging and many diseases. Oxidative stress is not actually a “disease” and does not show a specific clinical picture, but it hides behind the symptoms and signs of the underlying disease. In other words, we can only measure it if we perform certain biochemical tests. These tests can be set for different biological samples.
Pregnancy is a dynamic process during which systemic and local changes occur in the mother. All these changes are necessary for the normal development of the fetus. Disorders in this process can lead to complications in pregnancy, changes in the growth path of the fetus, premature birth, and some other conditions (e.g., treatment of preeclampsia and gestational diabetes or the need for caesarean section), intrauterine growth restriction (IUGR), and small or large infants for gestational age.
Homeostasis of the maternal environment is maintained through a variety of mediators, including hormones, cytokines, oxidative status, and diet. Factors that interfere with this homeostasis can be endogenous or exogenous and are inflammation, oxidative stress, exposure to chemical agents, and lack or excess of food, which can jeopardize the growth and development of the fetus. During pregnancy, there is an increase in oxidative stress, a phenomenon caused by the usual systemic inflammatory response, resulting in a large amount of reactive oxygen species in the circulation. The development and maturation of the placenta is a complex process that requires coordinated regulation of trophoblast invasion and its differentiation and spread in the maternal decidua.
This Special Issue is dedicated to all aspects of oxidative stress. We must take into account all extensions of oxidative stress, which also include the period before fertilization itself, and the entire duration of pregnancy and childbirth. However, we know that oxidative stress during pregnancy can lead to the development of certain disorders even in the later development of the child. When considering your submission, please keep in mind that IJMS is a journal of molecular science. However, submissions of clinical studies that include biomolecular experiments or pathological research with case sample data are welcomed.
Due to the success of Volume 1, we would like to add more results and new insights from recent research projects. You can find Volume 1 at the following link:
https://www.mdpi.com/journal/ijms/special_issues/OS_Pregnancy.
Prof. Dr. Joško Osredkar
Guest Editor
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Keywords
- oxidative stress
- angiogenesis
- hypertension in pregnancy
- preterm birth
- metabolic syndrome
- biomarkers
- toxic agents
- follicular fluid
- amniotic fluid
- cord blood
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