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Developmental Biology and Epigenetics in Female Reproduction and Disease
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Developmental Biology and Epigenetics in Female Reproduction and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 5011

Special Issue Editor

Dr. Yuki Muranishi

E-Mail Website
Guest Editor
Department of Life and Food Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan
Interests: mammals; human; developmental biology; gynecology; gene expression; disease; epigenetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We would like to invite you to contribute to a Special Issue of our journal that will focus on the epigenetics and developmental biology of reproductive health and disease in mammals. Recently, our studies have suggested that maternal stress during the perinatal period can cause developmental disorders and consequently affect the offspring in the biological systems of several animals (Biol Reprod., 2022; Animals, 2023). As guest editors of this Special Issue, we aim to bring together research on the latest advances in epigenetic regulation and its role in reproductive health and disease, with a particular emphasis on gynecological diseases such as ovarian and uterine cancers, endometriosis, infertility, and other related disorders.

Additionally, potential topics for submissions to this Special Issue may include, but are not limited to, the following:

  1. Epigenetic regulation of reproductive development and diseases, including ovarian and uterine cancers, endometriosis, and infertility;
  2. The impact of environmental and lifestyle factors on epigenetic modifications in reproductive health and disease;
  3. Transgenerational epigenetic effects in reproductive health and disease: epigenetic mechanisms underlying gene expression of reproductive development and diseases;
  4. The role of epigenetics in the regulation of gametogenesis and embryonic development;
  5. Epigenetic-based therapies and interventions for gynecological diseases through translational research from animals to humans;
  6. Emerging techniques and technologies for studying epigenetic regulation of reproductive health and disease.

We welcome original research papers, reviews, and perspectives for this Special Issue. Please feel free to contact us if you have any questions or require further information. We look forward to your contributions.

Dr. Yuki Muranishi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epigenetics
  • development
  • animal
  • genetics
  • human medicine
  • cell fate determination
  • gene expression
  • endocrine system

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Published Papers (3 papers)

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Research

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13 pages, 3152 KiB  
Article
Evaluation of Lipopolysaccharide and Interleukin-6 as Useful Screening Tool for Chronic Endometritis
by Erina Yoneda, Sangwoo Kim, Kisaki Tomita, Takashi Minase, Mitsunori Kayano, Hiroyuki Watanabe, Masafumi Tetsuka, Motoki Sasaki, Hiroshi Iwayama, Hideomi Sanai and Yuki Muranishi
Int. J. Mol. Sci. 2024, 25(4), 2017; https://doi.org/10.3390/ijms25042017 - 7 Feb 2024
Cited by 2 | Viewed by 1806
Abstract
Universal diagnostic criteria for chronic endometritis (CE) have not been established due to differences in study design among researchers and a lack of typical clinical cases. Lipopolysaccharides (LPSs) have been reported to cause inflammation in the reproductive systems of several animals. This study [...] Read more.
Universal diagnostic criteria for chronic endometritis (CE) have not been established due to differences in study design among researchers and a lack of typical clinical cases. Lipopolysaccharides (LPSs) have been reported to cause inflammation in the reproductive systems of several animals. This study aimed to elucidate the influence of LPS in the pathogenesis of CE in humans. We investigated whether LPS affected cytokine production and cell proliferation in the endometrium using in vivo and in vitro experiments. LPS concentrations were analyzed between control and CE patients using endometrial tissues. LPS administration stimulated the proliferation of EM-E6/E7 cells derived from human endometrial cells. High LPS concentrations were detected in CE patients. LPS concentration was found to correlate with IL-6 gene expression in the endometrium. Inflammation signaling evoked by LPS led to the onset of CE, since LPS stimulates inflammatory responses and cell cycles in the endometrium. We identified LPS and IL-6 as suitable candidate markers for the diagnosis of CE. Full article
(This article belongs to the Special Issue Developmental Biology and Epigenetics in Female Reproduction and Disease)
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23 pages, 6100 KiB  
Article
Transgenerational Transmission of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Effects in Human Granulosa Cells: The Role of MicroRNAs
by Laura Gaspari, Delphine Haouzi, Aurélie Gennetier, Gaby Granes, Alexandra Soler, Charles Sultan, Françoise Paris and Samir Hamamah
Int. J. Mol. Sci. 2024, 25(2), 1144; https://doi.org/10.3390/ijms25021144 - 17 Jan 2024
Viewed by 1210
Abstract
Endocrine-disrupting chemicals (EDCs) might contribute to the increase in female-specific cancers in Western countries. 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) is considered the “prototypical toxicant” to study EDCs’ effects on reproductive health. Epigenetic regulation by small noncoding RNAs (sncRNAs), such as microRNAs (miRNA), is crucial for controlling [...] Read more.
Endocrine-disrupting chemicals (EDCs) might contribute to the increase in female-specific cancers in Western countries. 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) is considered the “prototypical toxicant” to study EDCs’ effects on reproductive health. Epigenetic regulation by small noncoding RNAs (sncRNAs), such as microRNAs (miRNA), is crucial for controlling cancer development. The aim of this study was to analyze transcriptional activity and sncRNA expression changes in the KGN cell line after acute (3 h) and chronic (72 h) exposure to 10 nM TCDD in order to determine whether sncRNAs’ deregulation may contribute to transmitting TCDD effects to the subsequent cell generations (day 9 and day 14 after chronic exposure). Using Affymetrix GeneChip miRNA 4.0 arrays, 109 sncRNAs were found to be differentially expressed (fold change < −2 or >2; p-value < 0.05) between cells exposed or not (control) to TCDD for 3 h and 72 h and on day 9 and day 14 after chronic exposure. Ingenuity Pathway Analysis predicted that following the acute and chronic exposure of KGN cells, sncRNAs linked to cellular development, growth and proliferation were downregulated, and those linked to cancer promotion were upregulated on day 9 and day 14. These results indicated that TCDD-induced sncRNA dysregulation may have transgenerational cancer-promoting effects. Full article
(This article belongs to the Special Issue Developmental Biology and Epigenetics in Female Reproduction and Disease)
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Review

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16 pages, 4038 KiB  
Review
An Overview of Bioactive Compounds’ Role in Modulating the Nrf2/Keap1/NF-κB Pathway to Alleviate Lipopolysaccharide-Induced Endometritis
by Muhammad Zahoor Khan, Wenting Chen, Xiaotong Liu, Xiyan Kou, Adnan Khan, Rahat Ullah Khan, Muhammad Zahoor and Changfa Wang
Int. J. Mol. Sci. 2024, 25(19), 10319; https://doi.org/10.3390/ijms251910319 - 25 Sep 2024
Viewed by 837
Abstract
Endometritis is a common inflammatory condition of the uterine endometrial lining that primarily affects perinatal dairy animals and causes significant economic losses in agriculture. It is usually triggered by pathogenic bacteria and is associated with chronic postpartum reproductive tract infections. Bacterial lipopolysaccharides (LPSs) [...] Read more.
Endometritis is a common inflammatory condition of the uterine endometrial lining that primarily affects perinatal dairy animals and causes significant economic losses in agriculture. It is usually triggered by pathogenic bacteria and is associated with chronic postpartum reproductive tract infections. Bacterial lipopolysaccharides (LPSs) are known to increase levels of reactive oxygen species (ROS), leading to oxidative stress and inflammation through the activation of the NF-κB signaling pathway and the inhibition of Nrf2 nuclear translocation, which regulates antioxidant response elements (AREs). The effectiveness of the conventional management strategy involving antibiotics is decreasing due to resistance and residual concerns. This review explores the potential therapeutic benefits of targeting the Nrf2/Kelch-like ECH-associated protein 1 (Keap1)/NF-κB signaling pathway to alleviate LPS-induced endometritis. We discuss recent advancements in veterinary medicine that utilize exogenous antioxidants to modulate these pathways, thereby reducing oxidative stress and inflammatory responses in endometrial cells. This review highlights the efficacy of several bioactive compounds that enhance Nrf2 signaling and suppress NF-κB activation, offering protective effects against oxidative damage and inflammation. By examining various in vitro studies, this review emphasizes the emerging role of these signaling pathways in developing new therapeutic strategies that could potentially replace or supplement traditional treatments and mitigate the economic impacts of endometritis in livestock. Full article
(This article belongs to the Special Issue Developmental Biology and Epigenetics in Female Reproduction and Disease)
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