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Bioactive Compounds in Human Brain Structures and Diseases: 2nd Edition
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Bioactive Compounds in Human Brain Structures and Diseases: 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 1279

Special Issue Editor

Dr. Terezia Kiskova

E-Mail Website
Guest Editor
Institute of Pathology, Faculty of Medicine, Pavol Jozef Safarik University, 040 01 Kosice, Slovakia
Interests: brain cancer; molecular mechanism; natural compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Brain diseases are the leading cause of DALYs and the second-leading cause of death. As the brain is a vulnerable structure, it may be damaged during development as well as during adulthood. This Special Issue is focused on exploring how various bioactive compounds may lead to neuroprotection of the brain and prevent/treat brain diseases, such as neurodegenerative disorders, ischemic attacks, brain cancer, or depression.

This Special Issue welcomes original research and review papers demonstrating the molecular mechanisms of neuroprotection against brain injury using in vivo or in vitro models of animals, as well as studies conducted in clinical settings.

Dr. Terézia Kisková
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • brain
  • brain cancer
  • depression
  • neurodegenerative disorders
  • natural compounds

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Published Papers (1 paper)

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Research

21 pages, 3175 KiB  
Article
The First In Vivo Study Shows That Gyrophoric Acid Changes Behavior of Healthy Laboratory Rats
by Patrik Simko, Andrea Leskanicova, Maria Suvakova-Nunhart, Jan Koval, Nela Zidekova, Martina Karasova, Petra Majerova, Ludmila Verboova, Alzbeta Blicharova, Martin Kertys, Ivan Barvik, Andrej Kovac and Terezia Kiskova
Int. J. Mol. Sci. 2024, 25(12), 6782; https://doi.org/10.3390/ijms25126782 - 20 Jun 2024
Cited by 1 | Viewed by 879
Abstract
Gyrophoric acid (GA), a lichen secondary metabolite, has attracted more attention during the last years because of its potential biological effects. Until now, its effect in vivo has not yet been demonstrated. The aim of our study was to evaluate the basic physicochemical [...] Read more.
Gyrophoric acid (GA), a lichen secondary metabolite, has attracted more attention during the last years because of its potential biological effects. Until now, its effect in vivo has not yet been demonstrated. The aim of our study was to evaluate the basic physicochemical and pharmacokinetic properties of GA, which are directly associated with its biological activities. The stability of the GA in various pH was assessed by conducting repeated UV-VIS spectral measurements. Microsomal stability in rat liver microsomes was performed using Ultra-Performance LC/MS. Binding to human serum albumin (HSA) was assessed using synchronous fluorescence spectra, and molecular docking analysis was used to reveal the binding site of GA to HSA. In the in vivo experiment, 24 Sprague-Dawley rats (Velaz, Únetice, Czech Republic) were used. The animals were divided as follows. The first group (n = 6) included healthy males as control intact rats (♂INT), and the second group (n = 6) included healthy females as controls (♀INT). Groups three and four (♂GA/n = 6 and ♀GA/n = 6) consisted of animals with daily administered GA (10 mg/kg body weight) in an ethanol-water solution per os for a one-month period. We found that GA remained stable under various pH and temperature conditions. It bonded to human serum albumin with the binding constant 1.788 × 106 dm3mol−1 to reach the target tissue via this mechanism. In vivo, GA did not influence body mass gain, food, or fluid intake during the experiment. No liver toxicity was observed. However, GA increased the rearing frequency in behavioral tests (p < 0.01) and center crossings in the elevated plus-maze (p < 0.01 and p < 0.001, respectively). In addition, the time spent in the open arm was prolonged (p < 0.01 and p < 0.001, respectively). Notably, GA was able to pass through the blood–brain barrier, indicating its ability to permeate into the brain and to stimulate neurogenesis in the hilus and subgranular zone of the hippocampus. These observations highlight the potential role of GA in influencing brain function and neurogenesis. Full article
(This article belongs to the Special Issue Bioactive Compounds in Human Brain Structures and Diseases: 2nd Edition)
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