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Roles of Extracellular Vesicles in Cerebrovascular Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 2214

Special Issue Editor


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Guest Editor
Department of Biomedical Sciences, Joan C Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA
Interests: EV function; EV-based therapy for cerebrovascular disease; stroke; demantia; hypertension, aging

Special Issue Information

Dear Colleagues,

Cerebrovascular disease is a major contributor to later-life dementia, accounting for up to 20% of cases of dementia. A sedentary lifestyle, hypertension, diabetes, and aging are major risk factors for cerebrovascular diseases. Extracellular vesicles (EVs) are extracellular nanovesicles released by virtually cell lineages. In recent decades, much attention has been devoted to EVs as novel carriers of bioactive molecules such as proteins and genetic materials to influence the functions of cells/tissues nearby and distant. Because of their ability to cross the brain-blood barrier, EVs have the potential to serve as biomarkers and therapeutic carriers to deliver molecules into the brain. Emerging evidence indicates that circulating and brain-derived EVs might play a role in cerebrovascular diseases. However, how the circulating and/or brain-derived EVs secreted in physiological and pathological microenvironments differently affect the interactions of brain cells is largely unknown. In this regard, we invite investigators to contribute original research articles and reviews that stimulate the continuing efforts to understand EVs' roles and potential applications in cerebrovascular diseases such as stroke and hypertension- and aging-related dementia.

As the Guest Editor of this Special Issue, I hope this collection will be a useful reference for understanding EVs' roles and potential application in cerebrovascular diseases and their comorbidities.

We look forward to receiving your contributions.

Dr. Jinju Wang
Guest Editor

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Keywords

  • exosomes
  • cerebrovascular disease
  • stroke
  • hypertension-related dementia
  • aging-related dementia

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Published Papers (1 paper)

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Review

18 pages, 639 KiB  
Review
Extracellular Vesicles in Neurodegenerative Diseases: An Update
by Smara Sigdel, Sabrina Swenson and Jinju Wang
Int. J. Mol. Sci. 2023, 24(17), 13161; https://doi.org/10.3390/ijms241713161 - 24 Aug 2023
Cited by 5 | Viewed by 1862
Abstract
Neurodegenerative diseases affect millions of people worldwide. The likelihood of developing a neurodegenerative disease rises dramatically as life expectancy increases. Although it has drawn significant attention, there is still a lack of proper effective treatments for neurodegenerative disease because the mechanisms of its [...] Read more.
Neurodegenerative diseases affect millions of people worldwide. The likelihood of developing a neurodegenerative disease rises dramatically as life expectancy increases. Although it has drawn significant attention, there is still a lack of proper effective treatments for neurodegenerative disease because the mechanisms of its development and progression are largely unknown. Extracellular vesicles (EVs) are small bi-lipid layer-enclosed nanosized particles in tissues and biological fluids. EVs are emerging as novel intercellular messengers and regulate a series of biological responses. Increasing evidence suggests that EVs are involved in the pathogenesis of neurodegenerative disorders. In this review, we summarize the recent findings of EVs in neurodegenerative diseases and bring up the limitations in the field. Full article
(This article belongs to the Special Issue Roles of Extracellular Vesicles in Cerebrovascular Diseases)
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