Molecular Regulatory Mechanisms of Non-coding RNA in Cardiovascular Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 January 2025 | Viewed by 4880
Special Issue Editors
Interests: valve surgery; coronary surgery; aortic surgery; cardiac biomechanics; tissue biomodelling; tissue engineering; regenerative medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Research advances have highlighted the significant role of non-coding RNA (ncRNA) in cardiovascular disease and heart conditions. Specific long non-coding RNAs (lncRNAs) are closely associated with heart diseases like myocardial infarction and heart failure. MicroRNAs (miRNAs) regulate gene expression and impact cardiac cell proliferation and apoptosis in cardiovascular disease. Circular RNAs (circRNAs) act as miRNA sponges and modulate miRNA activity in heart diseases. Additionally, other ncRNAs, such as long non-coding circular RNAs (lncircRNAs) and transcription start site-associated RNAs (TSSRNAs), are implicated in cardiovascular disease. Dysregulated miRNAs are also linked to aortic dissection, degenerative mitral disease, aortic valve stenosis, heart tumors, and NSTEMI. Understanding the functions of ncRNAs and miRNAs in these conditions could improve diagnostics and targeted therapies for cardiovascular diseases.
Furthermore, the discovery of miRNA-associated extracellular vesicles, also known as miRNA-NETs, has provided new insights into the intercellular communication and pathogenesis of cardiovascular diseases. These vesicles contain miRNAs that can be released by various cell types, including platelets and endothelial cells, in response to injury or stress. MiRNA-NETs have been found to play a crucial role in modulating inflammation, thrombosis, and endothelial dysfunction, which are key processes involved in the development and progression of cardiovascular diseases such as atherosclerosis and myocardial infarction. Understanding the complex interactions between miRNA-NETs and target cells in the cardiovascular system holds great potential for the development of novel therapeutic strategies and diagnostic approaches. Further research in this area will deepen our understanding of the role of miRNA-NETs in cardiovascular diseases and pave the way for personalized medicine approaches in the management of these conditions.
Dr. Francesco Nappi
Dr. Sanjeet Avtaar Singh
Guest Editors
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Keywords
- non-coding RNA
- cardiovascular disease
- molecular regulation
- lncRNA
- miRNA
- circRNA
- gene expression
- pathogenesis
- heart disease
- therapeutic targets
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