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Telocytes and Other Interstitial Cells 3.0: From Structure to Function

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2092

Special Issue Editor

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue “Telocytes and Other Interstitial Cells 2.0: From Structure to Function”.

Interstitial cells are seen as any of the many cells that lies in connective tissue, filling the spaces between the functional tissue of an organ (parenchyma). Cells that use the name interstitial are found in many locations, such as the seminiferous tubules of the testes, and ovaries, the medulla and cortex of the kidney, etc. Moreover, in this category, we also include the interstitial cells of Cajal.

In recent years, special attention has been given to the telocytes, formerly known as interstitial Cajal-like cells. Telocytes represent a particular type of interstitial cells, seen as “connecting devices” integrating the overall information from the vascular, nervous and immune system, interstitium, and stem cells.

This Special Issue is devoted to recent progress in research onto interstitial cells in general. It also aims to form an opinion on the controversial role of telocytes and especially to see them integrated in the context of the concept of interstitial cells.

Outstanding experts interested in this thematic issue are very welcome to send original manuscripts and reviews dealing with any of the abovementioned cells.

Dr. Sanda Cretoiu
Guest Editor

Manuscript Submission Information

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Keywords

  • interstitial cells
  • interstitial cells of Cajal
  • telocytes
  • intercellular communication
  • extracellular vesicles

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Published Papers (1 paper)

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Research

24 pages, 11525 KiB  
Article
Telocytes/CD34+ Stromal Cells in the Normal, Hyperplastic, and Adenomatous Human Parathyroid Glands
by Lucio Díaz-Flores, Ricardo Gutiérrez, Miriam González-Gómez, Maria del Pino García, Jose Luis Carrasco, Juan Francisco Madrid and Lucio Díaz-Flores, Jr.
Int. J. Mol. Sci. 2023, 24(15), 12118; https://doi.org/10.3390/ijms241512118 - 28 Jul 2023
Cited by 4 | Viewed by 1551
Abstract
Telocytes/CD34+ stromal cells (TCs/CD34+ SCs) have been studied in numerous organs and tissues, but their presence and characteristics in the parathyroid glands have not been explored. Using immunological and ultrastructural procedures, we assess the location, arrangement, and behavior of TCs/CD34+ SCs in normal [...] Read more.
Telocytes/CD34+ stromal cells (TCs/CD34+ SCs) have been studied in numerous organs and tissues, but their presence and characteristics in the parathyroid glands have not been explored. Using immunological and ultrastructural procedures, we assess the location, arrangement, and behavior of TCs/CD34+ SCs in normal human parathyroids, during their development and in their most frequent pathologic conditions. In normal parathyroids, TCs/CD34+ SCs show a small somatic body and long thin processes with a moniliform aspect, form labyrinthine systems, connect other neighboring TCs/CD34+ SCs, vessels, adipocytes, and parenchymal cells directly or by extracellular vesicles, and associate with collagen I. TCs/CD34+ SCs and collagen I are absent around vessels and adipocytes within parenchymal clusters. In developing parathyroids, TCs/CD34+ SC surround small parenchymal nests and adipocytes. In hyperplastic parathyroids, TCs/CD34+ SCs are prominent in some thickened internodular septa and surround small extraglandular parenchymal cell nests. TCs/CD34+ SCs are present in delimiting regions with compressed parathyroids and their capsule in adenomas but absent in most adenomatous tissue. In conclusion, TCs/CD34+ SCs are an important cellular component in the human parathyroid stroma, except around vessels within parenchymal nests. They show typical characteristics, including those of connecting cells, are present in developing parathyroids, and participate in the most frequent parathyroid pathology, including hyperplastic and adenomatous parathyroids. Full article
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