Research on the Mechanism of Ferroptosis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 April 2025 | Viewed by 68
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Interests: antioxidants; sex differences; skin; melatonin; oxidative stress and cancer
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Interests: aging; human anatomy; morphology; oxidative stress; inflammation
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Special Issue Information
Dear Colleagues,
Ferroptosis is an iron-dependent, novel type of programmed cell death that is different from apoptosis and autophagy. The main mechanism of ferroptosis is that under the action of ferrous iron or esteroxygenase, it catalyzes the highly expressed unsaturated fatty acids on the cell membrane, causing lipid peroxidation, thereby inducing cell death; in addition, it is also manifested as a decrease in the regulatory core enzyme GPX4 of the antioxidant system (glutathione system).
Basic research often involves the study of various cell death modes, such as autophagy and apoptosis. Ferroptosis is a recently discovered cell death mode. At present, its morphology, biology, and mechanism pathways are partially understood, but the ferroptosis process involves multiple mechanisms and is precisely regulated by signal pathways. Therefore, further research on the mechanism of ferroptosis and its role in different types of diseases is important for finding therapeutic targets for related diseases and research on targeted drugs.
Prof. Dr. Rita Rezzani
Dr. Gaia Favero
Guest Editors
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Keywords
- ferroptosis
- programmed cell death
- targeted drugs
- therapeutic targets
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