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Impact of Diet on the Endocrine System: Insights into Cellular and Molecular Mechanisms

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 3378

Special Issue Editors

Dr. Gaia Favero

E-Mail Website
Guest Editor
Division of Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
Interests: aging; human anatomy; morphology; oxidative stress; inflammation
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Luca Vanella

E-Mail Website
Guest Editor
Department of Drug and Health Sciences, Section of Biochemistry, University of Catania, Catania, Italy
Interests: biochemistry; antioxidants; oxidative stress; heme oxygenase
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The endocrine system is a complex network of glands and organs. The hormones secreted from the endocrine tissues and organs control the whole body's metabolism; homeostasis; reproduction; growth and development; and response to injury, stress, and behaviours. Inter-individual factors (such as gender, age, nutritional status, gut microbiota, and circadian rhythms) together with external factors (environmental and behavioural) can significantly impact on the endocrine system, which in turn coordinates whole-body wellness.

A better understanding of how various nutritional and lifestyle factors can affect the endocrine system could be helpful in making smart dietary and lifestyle recommendations, thus managing the current challenge in maintaining a global health status. To promote biomedical and public health research, it is fundamental to explore the association and possible cellular and molecular mechanisms between nutritional and lifestyle factors from another perspective involving endocrine functions.

This Special Issue aims to (i) provide a comprehensive overview of the current knowledge on the cellular and molecular impacts of nutritional and lifestyle habits on the endocrine system, particularly focusing on anatomo-morphological, biochemical, molecular, and physiological aspects; and (ii) propose new therapeutical interventions exploiting the potential of nutraceutical products. Furthermore, this Special Issue will help in clarifying the undeniable role of the endocrine system in the genesis and progression of various diseases.

We welcome the submission of different article types to this collection, especially original research papers, reviews, and mini-reviews.

Dr. Gaia Favero
Prof. Dr. Luca Vanella
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidants
  • diet
  • endocrine system
  • ROS
  • lifestyle
  • nutraceuticals

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Published Papers (2 papers)

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Research

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13 pages, 2283 KiB  
Article
Predicting Food–Drug Interactions between Piperine and CYP3A4 Substrate Drugs Using PBPK Modeling
by Feifei Lin, Yingchun Hu, Yifan Zhang, Lijuan Zhao, Dafang Zhong and Jia Liu
Int. J. Mol. Sci. 2024, 25(20), 10955; https://doi.org/10.3390/ijms252010955 - 11 Oct 2024
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Abstract
Piperine has been reported to inhibit the enzyme activity of cytochrome P450 (CYP) 3A4. The aim of this study was to develop and validate a physiologically based pharmacokinetic (PBPK) model for piperine and to predict potential food–drug interactions (FDIs) between piperine and CYP3A4 [...] Read more.
Piperine has been reported to inhibit the enzyme activity of cytochrome P450 (CYP) 3A4. The aim of this study was to develop and validate a physiologically based pharmacokinetic (PBPK) model for piperine and to predict potential food–drug interactions (FDIs) between piperine and CYP3A4 substrate drugs using these models. The PBPK model for piperine was successfully developed and validated. Using this model, FDIs with ten CYP3A4 substrate drugs were simulated. The predicted area under the curve (AUC) ratios (with and without piperine, following a 7-day intake of 20 mg/day) for six drugs were found to exceed 1.25, with significant increases in AUC observed for ritonavir (31%), nifedipine (34%), cyclosporine (35%), triazolam (36%), alfentanil (39%), and simvastatin (59%) in humans. These findings suggest that caution should be exercised when consuming amounts of black pepper equivalent to a daily intake of 20 mg piperine during treatment with CYP3A4 substrate drugs, as it may significantly alter their pharmacokinetics. Full article
(This article belongs to the Special Issue Impact of Diet on the Endocrine System: Insights into Cellular and Molecular Mechanisms)
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Review

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39 pages, 2114 KiB  
Review
COVID-19-Associated Sepsis: Potential Role of Phytochemicals as Functional Foods and Nutraceuticals
by Bruno de Souza Goncalves, Darshan Sangani, Aleen Nayyar, Raghav Puri, Mahir Irtiza, Asma Nayyar, Abdelnaby Khalyfa, Komal Sodhi and Sneha S. Pillai
Int. J. Mol. Sci. 2024, 25(15), 8481; https://doi.org/10.3390/ijms25158481 - 3 Aug 2024
Viewed by 1927
Abstract
The acute manifestations of coronavirus disease 2019 (COVID-19) exhibit the hallmarks of sepsis-associated complications that reflect multiple organ failure. The inflammatory cytokine storm accompanied by an imbalance in the pro-inflammatory and anti-inflammatory host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection [...] Read more.
The acute manifestations of coronavirus disease 2019 (COVID-19) exhibit the hallmarks of sepsis-associated complications that reflect multiple organ failure. The inflammatory cytokine storm accompanied by an imbalance in the pro-inflammatory and anti-inflammatory host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to severe and critical septic shock. The sepsis signature in severely afflicted COVID-19 patients includes cellular reprogramming and organ dysfunction that leads to high mortality rates, emphasizing the importance of improved clinical care and advanced therapeutic interventions for sepsis associated with COVID-19. Phytochemicals of functional foods and nutraceutical importance have an incredible impact on the healthcare system, which includes the prevention and/or treatment of chronic diseases. Hence, in the present review, we aim to explore the pathogenesis of sepsis associated with COVID-19 that disrupts the physiological homeostasis of the body, resulting in severe organ damage. Furthermore, we have summarized the diverse pharmacological properties of some potent phytochemicals, which can be used as functional foods as well as nutraceuticals against sepsis-associated complications of SARS-CoV-2 infection. The phytochemicals explored in this article include quercetin, curcumin, luteolin, apigenin, resveratrol, and naringenin, which are the major phytoconstituents of our daily food intake. We have compiled the findings from various studies, including clinical trials in humans, to explore more into the therapeutic potential of each phytochemical against sepsis and COVID-19, which highlights their possible importance in sepsis-associated COVID-19 pathogenesis. We conclude that our review will open a new research avenue for exploring phytochemical-derived therapeutic agents for preventing or treating the life-threatening complications of sepsis associated with COVID-19. Full article
(This article belongs to the Special Issue Impact of Diet on the Endocrine System: Insights into Cellular and Molecular Mechanisms)
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