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SMART and Macromolecular Biomaterials: From Materials to Biology 2.0
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SMART and Macromolecular Biomaterials: From Materials to Biology 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: closed (20 September 2024) | Viewed by 3040

Special Issue Editors

Prof. Dr. Petr Humpolíček

E-Mail Website
Guest Editor
1. Faculty of Technology, Tomas Bata University in Zlín, Zlín, Czech Republic
2. Centre of Polymer Systems, Tomas Bata University in Zlín, Zlín, Czech Republic
Interests: polymer biomaterials; cell biology and genetics; polymer biocompatibility; biomimetic materials
Special Issues, Collections and Topics in MDPI journals
Dr. Marián Lehocký

E-Mail Website
Guest Editor
Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Trida Tomase Bati 5678, 760 01 Zlin, Czech Republic
Interests: polymer surfaces; surface modification; polymer–cell interaction; polymer surface characterization; polymer biomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

SMART biomaterials must meet a number of criteria, such as stimuli responsivity, the mimicking of the architecture of in vivo tissues and organs, and the induction of adequate cell and tissue reaction, and must be fabricated by reproducible technology. These aspects of biomaterials science, including chemistry, technology, cyto- and bio-compatibility, antimicrobial activity, novel experimental methods, and environmental aspects of biomaterials preparation are important topics for this Special Issue.

This Special Issue aims to bring together original research articles and topical reviews related to fundamental or applied research, which deals with SMART biomaterials preparation, characterization and their interactions with biological systems. This Special Issue will also focus on the description of molecular-level phenomena and the novel, advanced applications of active molecules in the above-mentioned systems.

Prof. Dr. Petr Humpolíček
Dr. Marián Lehocký
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • SMART materials
  • cytocompatibility
  • biocompatibility
  • technology

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Related Special Issue

Published Papers (2 papers)

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Research

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11 pages, 1036 KiB  
Communication
Comparison of Plasma-Polymerized Thin Films Deposited from 2-Methyl-2-oxazoline and 2-Ethyl-2-oxazoline: I Film Properties
by Pavel St’ahel, Věra Mazánková, Lubomír Prokeš, Vilma Buršíková, Monika Stupavská, Marián Lehocký, Hana Pištěková, Kadir Ozaltin and David Trunec
Int. J. Mol. Sci. 2023, 24(24), 17455; https://doi.org/10.3390/ijms242417455 - 14 Dec 2023
Cited by 2 | Viewed by 1273
Abstract
Poly(2-oxazoline) is a promising new class of polymeric materials due to their antibiofouling properties and good biocompatibility. Poly(2-oxazoline) coatings can be deposited on different substrates via plasma polymerization, which can be more advantageous than other coating methods. The aim of this study is [...] Read more.
Poly(2-oxazoline) is a promising new class of polymeric materials due to their antibiofouling properties and good biocompatibility. Poly(2-oxazoline) coatings can be deposited on different substrates via plasma polymerization, which can be more advantageous than other coating methods. The aim of this study is to deposit poly(2-oxazoline) coatings using a surface dielectric barrier discharge burning in nitrogen at atmospheric pressure using 2-methyl-2-oxazoline and 2-ethyl-2-oxazoline vapours as monomers and compare the film properties. For the comparison, the antibacterial and cytocompatibility tests were peformed according to ISO norms. The antibacterial tests showed that all the deposited films were highly active against Staphylococcus aureus and Escherichia coli bacteria. The chemical composition of the films was studied using FTIR and XPS, and the film surface’s properties were studied using AFM and surface energy measurement. The cytocompatibility tests showed good cytocompatibility of all the deposited films. However, the films deposited from 2-methyl-2-oxazoline exhibit better cytocompatibility. This difference can be explained by the different chemical compositions and surface morphologies of the films deposited from different monomers. Full article
(This article belongs to the Special Issue SMART and Macromolecular Biomaterials: From Materials to Biology 2.0)
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Review

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45 pages, 6014 KiB  
Review
Challenges and Pitfalls of Research Designs Involving Magnesium-Based Biomaterials: An Overview
by Nourhan Hassan, Thomas Krieg, Alexander Kopp, Alexander D. Bach and Nadja Kröger
Int. J. Mol. Sci. 2024, 25(11), 6242; https://doi.org/10.3390/ijms25116242 - 5 Jun 2024
Viewed by 1385
Abstract
Magnesium-based biomaterials hold remarkable promise for various clinical applications, offering advantages such as reduced stress-shielding and enhanced bone strengthening and vascular remodeling compared to traditional materials. However, ensuring the quality of preclinical research is crucial for the development of these implants. To achieve [...] Read more.
Magnesium-based biomaterials hold remarkable promise for various clinical applications, offering advantages such as reduced stress-shielding and enhanced bone strengthening and vascular remodeling compared to traditional materials. However, ensuring the quality of preclinical research is crucial for the development of these implants. To achieve implant success, an understanding of the cellular responses post-implantation, proper model selection, and good study design are crucial. There are several challenges to reaching a safe and effective translation of laboratory findings into clinical practice. The utilization of Mg-based biomedical devices eliminates the need for biomaterial removal surgery post-healing and mitigates adverse effects associated with permanent biomaterial implantation. However, the high corrosion rate of Mg-based implants poses challenges such as unexpected degradation, structural failure, hydrogen evolution, alkalization, and cytotoxicity. The biocompatibility and degradability of materials based on magnesium have been studied by many researchers in vitro; however, evaluations addressing the impact of the material in vivo still need to be improved. Several animal models, including rats, rabbits, dogs, and pigs, have been explored to assess the potential of magnesium-based materials. Moreover, strategies such as alloying and coating have been identified to enhance the degradation rate of magnesium-based materials in vivo to transform these challenges into opportunities. This review aims to explore the utilization of Mg implants across various biomedical applications within cellular (in vitro) and animal (in vivo) models. Full article
(This article belongs to the Special Issue SMART and Macromolecular Biomaterials: From Materials to Biology 2.0)
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