Neutrophil Extracellular Traps (NETs) in Immunity and Diseases, 3rd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 31 May 2025 | Viewed by 77
Special Issue Editor
Interests: neutrophils; neutrophil extracellular traps; pediatric diseases; pediatric cancers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is a continuation of our previous Special Issue “Neutrophil Extracellular Traps (NETs) in Immunity and Diseases: 2nd Edition” (https://www.mdpi.com/journal/ijms/special_issues/2I8LVEULI6).
Currently, research in this area has mainly focused on adaptive immune responses and the broad applications of NETs. Human death rates are highly influenced by diseases such as sepsis, multiresistant microbes, autoimmune disorders, and cancer, in which innate immunity plays a leading role. Therefore, greater attention should be paid to the innate immune response, and especially to neutrophils, which play an invaluable role in the host’s immune defense. Cytokines and other stimuli direct these cells into infected tissues, where they eliminate invading microbes. Notably, a successful neutrophil defense is often associated with inflammatory tissue damage and diseases including allergies, autoimmune diseases, atherosclerosis, thrombus formation, and metabolic disorders. These have been linked to the capability of activated neutrophils to release decondensed chromatin decorated with granular proteins known as neutrophil extracellular traps (NETs). NETs act as a scaffold for the aggregation of viable, necrotic, and apoptotic cells, as well as crystals and microbes. Importantly, under specific conditions, NETs act through either an inflammatory or anti-inflammatory process.
Although significant efforts have been made to study the release of NETs, we still need to broaden our knowledge of this unique feature of the innate immune response. Showing the contribution of NETs to various pathological conditions and the metastasis of cancer and gaining a deeper understanding of the mechanisms behind the release of NETs, as well as their role in the immune response and diseases, is of great importance. Additionally, the degradation of NETs and their clearance is only partially understood and warrants further research.
The focus of this Special Issue is on updating the current research on NETs in immunity and disease, improving our understanding of this phenomenon, and developing new therapeutic strategies for various pathological conditions related to the excessive release of NETs and/or their incomplete degradation. Both review and original articles covering basic, translational, or clinical molecular-data-supported research are welcome.
Dr. Jasmin Knopf
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neutrophils
- neutrophil functions
- neutrophil extracellular traps (NETs)
- NET biology
- NETs in autoimmune diseases
- NETs in immune response
- NETs in the development and progression of cancer diseases
- NETs in immunothrombosis
- degradation of NETs
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
