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Novel Insights into Regenerative Medicine
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Novel Insights into Regenerative Medicine

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 2947

Special Issue Editors

Prof. Dr. J. U. Carmona

E-Mail Website
Guest Editor
Grupo de Investigación Terapia Regenerativa, Departamento de Salud Animal, Universidad de Caldas, Manizales, Colombia
Interests: regenerative medicine; biomechanics; fracture; sports injuries; trauma surgery
Prof. Dr. Marco Tatullo

E-Mail Website
Guest Editor
Full Professor, Department of Translational Biomedicine and Neuroscience (DiBraiN), University of Bari “Aldo Moro”, 70121 Bari, Italy
Interests: regenerative medicine; regenerative dentistry; stem cells; MSCs; biomaterials; growth factors; PRF; PRP; tissue engineering; biomimetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Currently, it is more common to hear people and physicians worldwide speak out about how they are searching for new treatments based on cells and proteins that can solve old problems without the need for taking medications for life, and regenerative medicine emerges as an answer to these solicitudes.

Regenerative medicine encompasses a wide field of the biological sciences that combines several therapeutic approaches that include the use of cells, proteins, biomaterials, and genetic modifications at basic, preclinical, and clinical stages to heal, improve, or restore tissues and organs affected by traumatic, toxic, infectious, degenerative, immune, and genetic conditions, among others, instead of administering the classical pharmacological therapies for controlling lifetime symptoms.

In a wide sense, several regenerative medicine biodrugs and bioengineered-based products have changed the course of treating many diseases, such as stroke, hypoxic encephalopathy, osteoarthritis, tendinopathies, heart failure, renal chronic disease, and retinal degeneration, among others.

We invite passionate researchers of this field to contribute with reviews and research articles to give novel information encompassing insights into the realm of regenerative medicine from basic studies to bench-side therapies.

Prof. Dr. J. U. Carmona
Prof. Dr. Marco Tatullo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • regenerative medicine
  • tissue regeneration
  • stem cell
  • platelet-rich plasma
  • growth factors
  • cytokines
  • bioscaffolds
  • gels

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Published Papers (2 papers)

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Research

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18 pages, 7600 KiB  
Article
Effects of Two Decellularization Protocols on the Mechanical Behavior and Structural Properties of the Human Urethra
by Marcela Kuniakova, Zuzana Varchulova Novakova, Daniel Haspinger, Justyna Anna Niestrawska, Martin Klein, Paulina Galfiova, Jan Kovac, Michal Palkovic, Lubos Danisovic, Niels Hammer and Stanislav Ziaran
Int. J. Mol. Sci. 2024, 25(22), 12361; https://doi.org/10.3390/ijms252212361 - 18 Nov 2024
Viewed by 799
Abstract
This study evaluates the effects of two decellularization protocols, enzyme-detergent (ED) and detergent-detergent (DD), on the structural and biomechanical properties of human urethral tissue. Urethral samples from 18 individuals were divided into ED (n = 7) and DD (n = 11) [...] Read more.
This study evaluates the effects of two decellularization protocols, enzyme-detergent (ED) and detergent-detergent (DD), on the structural and biomechanical properties of human urethral tissue. Urethral samples from 18 individuals were divided into ED (n = 7) and DD (n = 11) groups, with native samples (n = 3) serving as controls. Histological and ultrastructural analyses confirmed that both protocols effectively removed cellular content while preserving essential extracellular matrix (ECM) elements, such as collagen and elastic fibers. Immunohistochemical staining for collagen IV and fibronectin revealed no significant differences between decellularized and native tissues, indicating intact ECM structure. Biomechanical testing demonstrated that DD-treated tissues had significantly lower Cauchy stress (1494.8 ± 518.4 kPa) when compared to native tissues (2439.7 ± 578.7 kPa, p = 0.013), while ED-treated tissues were similar to both groups. Both decellularized groups exhibited reduced stretch at failure and elastic modulus compared to native tissues. Cytotoxicity assays using adipose-derived stem cells demonstrated no signs of toxicity in either protocol. Overall, both ED and DD protocols effectively preserved the urethral ECM structure and mechanical properties, making them suitable for potential use in tissue-engineered grafts and for biobanking purposes. Further research is needed to refine and optimize decellularization methods to improve scaffold recellularization and ensure clinical safety and efficacy. Full article
(This article belongs to the Special Issue Novel Insights into Regenerative Medicine)
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Review

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37 pages, 2608 KiB  
Review
Biologic Brachytherapy: Genetically Modified Surgical Flap as a Therapeutic Tool—A Systematic Review of Animal Studies
by Wiktor Pascal, Mateusz Gotowiec, Antoni Smoliński, Michał Suchecki, Michał Kopka, Adriana M. Pascal and Paweł K. Włodarski
Int. J. Mol. Sci. 2024, 25(19), 10330; https://doi.org/10.3390/ijms251910330 - 25 Sep 2024
Viewed by 1507
Abstract
Surgical flaps are rudimentary tools in reconstructive surgery, especially following extensive solid tumour resections. They cover skin and soft tissue defects but are prone to ischaemia and necrosis. Since their primary aim is reconstruction, they rarely exhibit a therapeutic activity against the treated [...] Read more.
Surgical flaps are rudimentary tools in reconstructive surgery, especially following extensive solid tumour resections. They cover skin and soft tissue defects but are prone to ischaemia and necrosis. Since their primary aim is reconstruction, they rarely exhibit a therapeutic activity against the treated disease. Attempts have been made to develop a new therapeutic strategy—biologic brachytherapy, which uses genetically engineered surgical flaps as a drug delivery vehicle, allowing the flap tissue to act as a “biologic pump”. This systematic review summarizes the preclinical evidence on using genetically modified surgical flaps. A literature search was conducted in PubMed, EMBASE, Scopus and Web of Science. The initial literature search yielded 714 papers, and, eventually, seventy-seven studies were included in qualitative analysis. The results show that genetic enhancement of flaps has been used as a local or systemic therapy for numerous disease models. Frequently, it has been used to increase flap survival and limit ischaemia or promote flap survival in a non-ischemic context, with some studies focusing on optimizing the technique of such gene therapy. The results show that genetically modified flaps can be successfully used in a variety of contexts, but we need more studies to implement this research into specific clinical scenarios. Full article
(This article belongs to the Special Issue Novel Insights into Regenerative Medicine)
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