Non-small Cell Lung Cancer: From Molecular Mechanisms to Therapeutic Strategies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 January 2025 | Viewed by 2767
Special Issue Editor
Special Issue Information
Dear Colleagues,
In the modern era, the treatment landscape for non-small cell lung cancer (NSCLC) has undergone a significant transformation due to the introduction of Immune checkpoint inhibitors (ICIs), either alone or in combination with chemotherapy, and targeted therapies (TT) both in early and advanced stages. Additionally, novel treatment options, such as antibody–drug conjugates (ADCs), offer new possibilities in the fight against lung cancer. Precision oncology plays a critical role in guiding treatment decisions, not only based on the molecular profile of the tumor at baseline but also considering molecular/histological changes at disease progression. Extensive efforts have been made in recent decades to evaluate the efficacy and safety of current treatment strategies, particularly ICIs, in "special populations" such as elderly patients, those with poor ECOG performance status, and those with comorbidities like chronic viral infections.
This Special Issue aims to gather original and review articles that focus on assessing the efficacy and safety of current and novel therapies in both oncogene-addicted and non-oncogene-addicted NSCLC, as well as the evaluation of potential predictive and prognostic molecular biomarkers. We encourage authors to submit original or review articles that investigate the role of novel treatments in "special populations" affected by NSCLC in order to enhance our understanding of their impact in these patient subgroups.
Dr. Lorenzo Belluomini
Guest Editor
Manuscript Submission Information
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Keywords
- NSCLC
- predictive and prognostic biomarkers
- immunotherapy
- targeted therapy
- special populations
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