The Multiple Faces of Non-small Cell Lung Cancer: Targeted Therapies and Recent Developments
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 June 2025 | Viewed by 1641
Special Issue Editors
Interests: lung cancer; mesothelioma; phase 1 clinical trials; targeted therapies; next generation sequencing
Interests: lung cancer; adjuvant therapy; minimal residual disease; targeted therapies; next generation sequencing; liquid biopsy
Special Issue Information
Dear Colleagues,
Knowledge of biology of Non-small Cell Lung Cancer has increased in the last years. The use of next generation sequencing (NGS) has permitted to divide this disease in many diseases, according to the presence of molecular drivers. For eight of these oncogene-addicted tumours, targeted therapies have been approved: mutations of EGFR, BRAF, MET, KRAS and rearrangements of ALK, ROS1, RET and NTRK have specific tyrosin-kinase inhibitors (TKIs) that have changed the natural history of these diseases. However, innate and acquired resistances are able to limit the activity of TKIs. For this reason, many efforts are ongoing to understand biology of resistances in order to identify further therapeutic approaches. Several new drugs are entering in the therapeutic strategy of many of those types of tumors. Moreover immune-conjugates represents a new option to target tumoral cells with mechanisms of action different from those of TKIs. Finally the use of NGS may identify molecular features for which less is still known without clear indications of therapy. These situations may arise difficulties in identify the correct therapeutic strategy. This Special issue will focus on targeted therapies for NSCLC and on recent developments in term of biology and new drugs in this field.
Dr. Angelo Delmonte
Dr. Alberto Verlicchi
Guest Editors
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Keywords
- non-small cell lung cancer
- tyrosine-kinase inhibitors
- next generation sequencing
- immunoconjugates
- targeted therapies
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