Advances in Purinergic Signaling
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (15 April 2023) | Viewed by 1878
Special Issue Editor
Interests: oxidative stress; purinergic system; inflammation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Proposed in 1972, purinergic signaling is characterized by the relationship between signaling components, receptors, and specific enzymes. The purinergic system is characterized by the action of extracellular nucleotides and nucleosides that are degraded by the action of several ectonucleotidases. ATP is an intracellular energy molecule, but it can be released from various types of cells after damage. Thus, after release, it can activate receptors or be rapidly decomposed by ectonucleotidases. Purinergic signaling receptors are classified into two main groups: P1 nucleoside receptors and P2 purinoceptors. All cells have components of the purinergic system and can release nucleotides in a controlled situation. It is now established that changes in purinergic signaling are involved in the therapy of many diseases, in addition to being related to the effects of physical exercise and nutraceutical molecules on the body. This Special Issue aims to present and discuss the advancement of research and innovative therapies involving the purinergic system and diseases with a high impact on society, such as diabetes, hypertension, atherosclerosis, heart disease, cancer, and chronic kidney disease, neurological diseases, such as epilepsy, and neurodegenerative ones, such as Alzheimer's and Parkinson's diseases as well as multiple sclerosis, with the possibility of involving communicable and chronic diseases emerging.
Dr. Margarete Dulce Bagatini
Guest Editor
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Keywords
- purinergic receptors
- ectonucleotidases
- nucleotides
- nucleoside
- ATP
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