Alzheimer’s Disease and Other Dementias—Molecular Therapeutic Approaches
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 May 2025 | Viewed by 3551
Special Issue Editors
Interests: Alzheimer's disease; tauopathy; neurodegeneration; animal models
Special Issues, Collections and Topics in MDPI journals
Interests: neuroinflammation; astrocyte; microglia; Alzheimer’s disease; animal model
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Although Alzheimer's disease (AD) and other dementias are being intensively investigated, there is not yet a drug that efficiently interferes with disease pathogenesis. Most cases of AD are sporadic and less than 5%, among them carrying mutations that affect beta amyloid, are early‐onset familial AD that occur before the age of 65 years. Unfortunately, thus far, most of the newly developed drugs for AD treatment have failed in clinical trials. There is an urgent need for new therapies for treating dementias, particularly AD. Otherwise, this disease will continue to attack 5% of people aged over 65 and more than 40% of those aged over 85. Genetic risk factors, such as the presence of ApoE4 or mutations in inflammatory markers, such as TREM2, have been shown to affect disease development and progress. However, preventive approaches, such as maintaining good health (e.g., reducing cardiovascular and metabolic risk factors, enhancing physical and mental activities), seem to have a major impact on reducing disease incidence and delaying its onset. Many research approaches may be suitable for combating dementias, such as identifying disease-causing compounds (toxins), finding new targets, developing new drugs (mono/multi-target) by drug screening or by drug design, cell or organelle therapy, and device development, as well as other creative and innovative unconventional approaches.
This Special Issue will be dedicated to gathering novel therapeutic approaches to treat Alzheimer's disease and other dementias. We welcome submissions, including original papers and reviews, on these essential topics.
Prof. Dr. Hanna Rosenmann
Prof. Dr. Dan Frenkel
Guest Editors
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Keywords
- dementia
- prevention of dementia
- treatment of dementia
- amyloid tangles
- tauopathies
- mild cognitive impairment
- neurodegenerative pathways
- toxic elements inducing dementia
- drug screening
- drug design
- cell or organelle therapy
- device development
- neurodegeneration
- neuroinflammation
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