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Recent Advances in Melanoma

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 42

Special Issue Editors

Special Issue Information

Dear Colleagues,

Melanoma represents the most rapidly increasing malignancy with a high mortality rate. Despite groundbreaking new treatments, e.g., combination of anti-PD-1 and anti-CTLA-4 immunotherapy or targeted therapy (inhibition of BRAF/MEK kinases), the overall responses rates in patients with metastatic melanoma reach the level of 58% and 78%, respectively. Thus, new agents with additional anti-tumour capacities are highly desired. To date, studies looking at the outcomes from the advancement of anti-melanoma drugs have described that pre-operative therapy can extend survival rates after surgery. Nonetheless, no selective therapeutic options have been accepted as the basal adjuvant or neoadjuvant background for drug-resistant melanoma, and a substantial number of melanoma patients have died; therefore, unmet medical needs have consistently increased. As a result, anti-melanoma drug resistance remains a fundamental challenge in the treatment of patients with advance melanoma.

The goal of enclosed Special Issue is to collect the latest findings on a broad range of research including basic research in vitro, preclinical models involving substances potentially used as breakthrough clinical solutions for drug-resistant tumours as well as the newly introduced compounds targeting melanoma therapy. We welcome original experimental research, review articles, and commentary articles describing different aspects of this devastating disease. Articles on melanoma diagnosis and on mechanisms underlying melanomagenesis and melanoma progression are also invited.

Prof. Dr. Andrzej Slominski
Dr. Konrad Kleszczyński
Guest Editors

Manuscript Submission Information

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Keywords

  • melanoma
  • anti-cancer
  • immunotherapy
  • targeted therapy
  • signaling pathway
  • pharmacotherapy
  • biomarkers
  • clinical outcome
  • combination immunotherapy
  • mitochondria
  • dermatoendocrinology
  • skin therapy

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Published Papers

This special issue is now open for submission.
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