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Regenerative Medicine: Biomaterials and Stem Cell Research

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 728

Special Issue Editor


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Guest Editor
Grupo de Investigación en Terapia Celular y Medicina Regenerativa, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Servizo Galego de Saúde (SERGAS), 15006 A Coruña, Spain
Interests: tissue engineering; regenerative medicine; cell therapy; bioprinting; stem cells

Special Issue Information

Dear Colleagues,

Regenerative medicine is an emerging field that combines biomaterials and stem cells to repair, replace, or regenerate damaged tissues and organs. Biomaterials provide structural and biochemical support that facilitates tissue regeneration. They are designed to be biocompatible and, in many cases, biodegradable, allowing them to integrate safely into the body.

Stem cells, with their unique ability to differentiate into various types of specialized cells, are essential in this field. These cells can be obtained from various sources, such as embryonic, adult, and induced pluripotent stem cells (iPSCs). Research focuses on optimizing the conditions for the growth and differentiation of these cells in combination with suitable biomaterials.

This Special Issue wants to focus on both basic and clinical studies that incorporate biomolecular experiments to have a more complete comprehension on how the integration of biomaterials and stem cells in regenerative medicine is revolutionizing the ability to treat degenerative diseases, severe injuries, and the scarcity of organs for transplants, offering new hope for improving patients’ quality of life.

Dr. Silvia María Díaz-Prado
Guest Editor

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Keywords

  • regenerative medicine
  • stem cell
  • biomaterial
  • bioprinting
  • tissue engineering
  • tissue and organ transplant
  • organ scarcity

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Published Papers (1 paper)

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Research

14 pages, 787 KiB  
Article
Morphometric, Biomechanical and Histologic Assessment of Physiologic Ovine Cervical Intervertebral Disc: An Experimental Study and Brief Literature Review
by Nikolaos Gkantsinikoudis, Savvas Koltsakidis, Panagiotis Prodromou, Eleni Aggelidou, Stylianos Kapetanakis, Eleftherios Tsiridis, Ioannis Magras, Dimitra Psalla, George Kazakos, Dimitrios Tzetzis and Aristeidis Kritis
Int. J. Mol. Sci. 2024, 25(23), 12579; https://doi.org/10.3390/ijms252312579 - 22 Nov 2024
Viewed by 281
Abstract
The ovine cervical spine model has been established as a representative model of the human cervical spine in the current literature, and is the most commonly used large animal model in studies investigating pathogenesis and treatment strategies for intervertebral disc (IVD) degeneration. However, [...] Read more.
The ovine cervical spine model has been established as a representative model of the human cervical spine in the current literature, and is the most commonly used large animal model in studies investigating pathogenesis and treatment strategies for intervertebral disc (IVD) degeneration. However, existing data regarding morphometry, biomechanical profiles and the microscopic features of a physiological ovine cervical IVD remain scarce. Hence, the aim of this study was to perform a multimodal morphometric, biomechanical and histologic evaluation of a normal ovine cervical IVD. For this purpose, nine ovine cervical IVDs were harvested from three female sheep, and subjected to morphometrical, biomechanical and histologic analyses. The biomechanical assessment included the performance of cyclic compression, creepand compressive strength tests in a controlledlaboratory environment. Histological evaluation was performed using hematoxylin–eosin, Masson’s trichrome and Alcian blue staining. The results from the morphometric analysis showed that the range of disc heights was 4–9 mm in all surfaces, featuring a constant increase from cranial to caudal levels. Biomechanical evaluation revealed that cyclic loading for 20 cycles was necessary for preconditioning so that the repeatability of the force–displacement hysteresis response is present. The critical failure point was defined at 15.5 MPa, whereas Young’s modulus of elasticity was 1.2 MPa. The histologic assessment demonstrated the presence of a concentric arrangement of collagen lamellae in external annulus fibrosus, along with the sparsely organized internal nucleus pulposus. Ovine cervical IVD represents a complex structure with distinct features that should be considered by researchers in this field in order to optimize the reliability and validity of testing results. Full article
(This article belongs to the Special Issue Regenerative Medicine: Biomaterials and Stem Cell Research)
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