CoA in Health and Disease 3.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 20 February 2025 | Viewed by 2932
Special Issue Editor
Interests: physiology; endocrinology; metabolism; lipids; lipogenesis; lipolysis; stearoyl-CoA desaturase; angiogenesis; cardiovascular system; mitochondria; obesity; type 2 diabetes; transcription factors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
CoA and its thioester derivatives are crucial components of numerous biosynthetic and degradative pathways of cellular metabolism (including the synthesis and oxidation of fatty acids, the Krebs cycle, ketogenesis, the biosynthesis of cholesterol and acetylcholine, and the degradation of amino acids), post-translational modifications of proteins, and the regulation of gene expression. Consequently, it is not surprising that the abnormal biosynthesis of CoA/CoA derivatives is associated with numerous pathologies, including diabetes, neurodegeneration, Reye’s syndrome, vitamin B12 deficiency, cardiac hypertrophy, and cancer. This Special Issue of the IJMS will showcase selected novel research articles covering the multiple roles of CoA and its derivatives in extracellular and intracellular signaling functions in physiology and pathology.
Topics of interest to this Special Issue include, but are not limited to, the following:
- CoA synthesis and degradation;
- CoA transport and mitochondria;
- Extracellular functions of CoA/CoA thioesters;
- CoA/CoA thioesters as intracellular signaling molecules;
- Physiological and pathological changes in cellular CoA concentrations;
- Interconversion between CoA and its thioester derivatives in health and disease;
- The roles of nutrients, hormones, and other factors in the regulation of CoA levels in cells;
- Acyl-CoA metabolism;
- Association of CoA/acyl-CoA with fatty acid metabolism.
In addition, critical reviews of the status and perspectives regarding the role of CoA in pathophysiology are welcomed.
Dr. Pawel Dobrzyn
Guest Editor
Manuscript Submission Information
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Keywords
- energy production
- impaired metabolism
- Acyl-CoA synthesis and function
- Acetyl-CoA
- CoA analogues
- oxidative stress
- hereditary diseases
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