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Nanomaterials and Biomaterials in Biomedicine Application
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Nanomaterials and Biomaterials in Biomedicine Application

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 3588

Special Issue Editor

Dr. Filipa Mascarenhas-Melo

E-Mail Website
Guest Editor
1. Higher School of Health, Polytechnic Institute of Guarda, Rua da Cadeia, 6300-307 Guarda, Portugal
2. REQUIMTE/LAQV, Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Azinhaga Sta. Comba, 3000-548 Coimbra, Portugal
Interests: biomedicine; pharmaceutical issues; nanotechnology; drug delivery systems; skincare; additive manufacturing; nanomaterials; biomaterials; quality management systems; ISO standards; good practices
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to highlight the transformative role of nanomaterials and biomaterials in the field of biomedicine, exploring their applications and impact on healthcare technologies. Nanotechnology has emerged as a promising frontier, enabling precise manipulation at the nanometer scale for diagnostic, therapeutic, and imaging purposes. At the same time, biomaterials play a key role in designing biocompatible platforms and promoting advances in drug delivery, tissue engineering, and regenerative medicine.

The contributions in this Special Issue aim to disseminate cutting-edge research that addresses challenges and presents innovative solutions at the intersection of nanotechnology and biomaterials in biomedicine. Key themes include the development of multifunctional nanocarriers for drug delivery, the integration of nanomaterials to improve diagnostics and therapeutics, and the use of biomaterials in tissue engineering for regenerative medicine applications. In addition, ethical considerations and safety aspects related to the use of these advanced materials are welcomed.

By focusing on diverse perspectives, this Special Issue aims to provide a comprehensive overview of recent advances, promising trends, and future directions in harnessing the potential of nanomaterials and biomaterials to revolutionize biomedicine. The fusion of knowledge from multidisciplinary research fields contributes to the ongoing discussion about translating these innovations into tangible clinical applications.

Dr. Filipa Mascarenhas-Melo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • biomaterials
  • biomedicine
  • drug delivery
  • regenerative medicine
  • healthcare technologies
  • biocompatible platforms

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Published Papers (3 papers)

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Research

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18 pages, 2959 KiB  
Article
Laccase-Treated Polystyrene Surfaces with Caffeic Acid, Dopamine, and L-3,4-Dihydroxyphenylalanine Substrates Facilitate the Proliferation of Melanocytes and Embryonal Carcinoma Cells NTERA-2
by Hanluo Li, Martin Wilhelm, Christina Marie Baumbach, Michael C. Hacker, Michael Szardenings, Klaus Rischka, Andreas Koenig, Ellen Schulz-Kornas, Florian Fuchs, Jan Christoph Simon, Bernd Lethaus and Vuk Savković
Int. J. Mol. Sci. 2024, 25(11), 5927; https://doi.org/10.3390/ijms25115927 - 29 May 2024
Viewed by 839
Abstract
This study presents the effects of treating polystyrene (PS) cell culture plastic with oxidoreductase enzyme laccase and the catechol substrates caffeic acid (CA), L-DOPA, and dopamine on the culturing of normal human epidermal melanocytes (NHEMs) and human embryonal carcinoma cells (NTERA-2). The laccase–substrate [...] Read more.
This study presents the effects of treating polystyrene (PS) cell culture plastic with oxidoreductase enzyme laccase and the catechol substrates caffeic acid (CA), L-DOPA, and dopamine on the culturing of normal human epidermal melanocytes (NHEMs) and human embryonal carcinoma cells (NTERA-2). The laccase–substrate treatment improved PS hydrophilicity and roughness, increasing NHEM and NTERA-2 adherence, proliferation, and NHEM melanogenesis to a level comparable with conventional plasma treatment. Cell adherence dynamics and proliferation were evaluated. The NHEM endpoint function was quantified by measuring melanin content. PS surfaces treated with laccase and its substrates demonstrated the forming of polymer-like structures. The surface texture roughness gradient and the peak curvature were higher on PS treated with a combination of laccase and substrates than laccase alone. The number of adherent NHEM and NTERA-2 was significantly higher than on the untreated surface. The proliferation of NHEM and NTERA-2 correspondingly increased on treated surfaces. NHEM melanin content was enhanced 6-10-fold on treated surfaces. In summary, laccase- and laccase–substrate-modified PS possess improved PS surface chemistry/hydrophilicity and altered roughness compared to untreated and plasma-treated surfaces, facilitating cellular adherence, subsequent proliferation, and exertion of the melanotic phenotype. The presented technology is easy to apply and creates a promising custom-made, substrate-based, cell-type-specific platform for both 2D and 3D cell culture. Full article
(This article belongs to the Special Issue Nanomaterials and Biomaterials in Biomedicine Application)
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15 pages, 4171 KiB  
Article
The Influence of the Variable Wettability Characteristics of Layers on the Transport of Nanoparticles in the Context of Drug Delivery in Skin Structures
by Mariola M. Błaszczyk, Łukasz Przybysz and Aleksandra Budzyń
Int. J. Mol. Sci. 2024, 25(9), 4665; https://doi.org/10.3390/ijms25094665 - 25 Apr 2024
Viewed by 897
Abstract
The rapid development of nanotechnology has offered the possibility of creating nanosystems that can be used as drug carriers. The use of such carriers offers real opportunities for the development of non-invasive drug delivery through skin structures. However, in addition to the ability [...] Read more.
The rapid development of nanotechnology has offered the possibility of creating nanosystems that can be used as drug carriers. The use of such carriers offers real opportunities for the development of non-invasive drug delivery through skin structures. However, in addition to the ability to create suitable nanocarriers, it is also necessary to know how they move through dermal layers. The human skin consists of layers with different wettability characteristics, which greatly complicates how introduced substances move through it. In this work, an experimental study of the diffusion process of nanoparticles through partitions with different wettability properties was carried out. Conventional diffusion tests using Franz chambers were used for this purpose. We quantified how the wettability of the barrier, the number of layers, and their mutual configuration affect the transport of nanoparticles. Based on the results, an analysis of the phenomena taking place, depending on the wettability of the partition, was carried out. A model relationship was also proposed to determine the effective diffusion coefficient, taking into account the influence of the wettability and porosity of the barrier. Full article
(This article belongs to the Special Issue Nanomaterials and Biomaterials in Biomedicine Application)
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Review

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20 pages, 2872 KiB  
Review
Targeted Clindamycin Delivery Systems: Promising Options for Preventing and Treating Bacterial Infections Using Biomaterials
by Dagmara Słota, Josef Jampilek and Agnieszka Sobczak-Kupiec
Int. J. Mol. Sci. 2024, 25(8), 4386; https://doi.org/10.3390/ijms25084386 - 16 Apr 2024
Viewed by 1343
Abstract
Targeted therapy represents a real opportunity to improve the health and lives of patients. Developments in this field are confirmed by the fact that the global market for drug carriers was worth nearly $40 million in 2022. For this reason, materials engineering and [...] Read more.
Targeted therapy represents a real opportunity to improve the health and lives of patients. Developments in this field are confirmed by the fact that the global market for drug carriers was worth nearly $40 million in 2022. For this reason, materials engineering and the development of new drug carrier compositions for targeted therapy has become a key area of research in pharmaceutical drug delivery in recent years. Ceramics, polymers, and metals, as well as composites, are of great interest, as when they are appropriately processed or combined with each other, it is possible to obtain biomaterials for hard tissues, soft tissues, and skin applications. After appropriate modification, these materials can release the drug directly at the site requiring a therapeutic effect. This brief literature review characterizes routes of drug delivery into the body and discusses biomaterials from different groups, options for their modification with clindamycin, an antibiotic used for infections caused by aerobic and anaerobic Gram-positive bacteria, and different methods for the final processing of carriers. Examples of coating materials for skin wound healing, acne therapy, and bone tissue fillers are given. Furthermore, the reasons why the use of antibiotic therapy is crucial for a smooth and successful recovery and the risks of bacterial infections are explained. It was demonstrated that there is no single proven delivery scheme, and that the drug can be successfully released from different carriers depending on the destination. Full article
(This article belongs to the Special Issue Nanomaterials and Biomaterials in Biomedicine Application)
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