Molecular Pathogenesis of Ischemic and Hemorrhagic Strokes
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (30 August 2024) | Viewed by 2608
Special Issue Editor
Interests: ischemic stroke in diabetes; diabetic foot; Anderson-Fabry disease; cytokines
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Based on its etiology, stroke can be classified into ischemic or hemorrhagic subtypes. Hypertension, diabetes, obesity, dyslipidemia, physical inactivity and cardiovascular disorders are the main modifiable risk factors.
Understanding the molecular mechanisms mediating each of these risk factors is expected to contribute significantly to reducing stroke risk, preventing neural damage, improving rehabilitation, and designing appropriate treatments. Abnormalities in the structure of the blood–brain barrier and blood vessels, thrombosis, vasoconstriction, atherosclerosis, reduced cerebral blood flow, neural oxidative stress, inflammation and apoptosis, reduced synaptic transmission, excitotoxicity, and altered expression/activity of many signaling channels and proteins are the best known mechanisms responsible for stroke induction.
The role of cerebral amyloid angiopathy (CAA) in hemorrhagic stroke has not yet been fully elucidated, and its role in ischemic stroke also remains unclear and worthy of further investigation.
This Special Issue of the International Journal of Molecular Sciences entitled “Molecular Pathogenesis of Ischemic and Hemorrhagic Strokes” will present studies that address the molecular pathogenesis of cerebrovascular damage due to the principal cerebrovascular risk factors such as hypertension, diabetes, dyslipidemia, inflammation, and physical inactivity. This Special Issue will also showcase research that focuses on the role of amyloid angiopathy in the pathogenesis of hemorrhagic stroke and examines the possible role of amyloid as possible pathogenetic stroke in vascular damage mechanisms linked to the different subtypes of ischemic stroke.
Prof. Dr. Antonino Tuttolomondo
Guest Editor
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Keywords
- stroke
- ischemic stroke
- hemorrhagic stroke
- hypertension
- dyslipidemia
- cerebral amyloid angiopathy
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