Immune Evasion and Pathological Prognostic Biomarkers in Bladder Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 December 2024 | Viewed by 2370
Special Issue Editors
Interests: bladder cancer; hepatocellular carcinoma; colorectal cancer
Special Issues, Collections and Topics in MDPI journals
Interests: immune regulation; regulatory cells; innate lymphoid cells; allergy; atopic dermatitis; rheumatoid arthritis; autoimmune diseases; immune evasion
Special Issue Information
Dear Colleagues,
Bladder cancer is a prevalent malignant condition worldwide, and its mortality rates vary depending on the subtype. Non-muscle invasive tumors that grow on the inner surface of the bladder generally have a better prognosis, whereas muscle-invasive or metastatic bladder cancer poses significant challenges and leads to poor patient outcomes. In the case of non-muscle invasive bladder cancer (NMIBC), especially in high-risk groups, numerous studies have investigated the prognosis of the immune response in combination with early-age Bacillus Calmette-Guérin (BCG) treatment. Recent advances in cancer biology and immunology have shed light on the complex interaction between the tumor microenvironment and the immune system of the host, specifically in the context of bladder cancer.
Within the tumor microenvironment, immune molecules and cells display a complex and ambivalent nature, influencing the delicate equilibrium between tumor elimination and the suppression of antitumor immune responses. Therefore, it is crucial to elucidate prognostic immunological molecular biomarkers associated with tumor progression and decipher the mechanisms underlying immune evasion and tumor-mediated immunosuppression. These efforts are pivotal in optimizing prognosis and developing effective treatment strategies.
Given the clinical significance of bladder cancer, the objective of this Special Issue, titled "Immune Evasion and Pathological Prognostic Biomarkers in Bladder Cancer", is to unravel and target pertinent biomarkers within the tumor microenvironment that have potential in immunological diagnosis, prognostication, and understanding immune evasion mechanisms. Bladder cancer is characterized by a high recurrence rate and sensitivity to anticancer drugs, underscoring the urgency to generate contemporary research findings and evidence-based recommendations to enhance treatment modalities.
By addressing these aforementioned aspects, this Special Issue aims to provide an updated and comprehensive understanding of the immunological landscape of bladder cancer, ultimately facilitating the development of personalized therapeutic approaches and improving patient outcomes.
We have already run a number of Special Issues; see:
https://www.mdpi.com/journal/ijms/special_issues
Dr. Sun-Hee Leem
Dr. Hyuk Soon Kim
Guest Editors
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Keywords
- bladder cancer
- immune evasion
- tumor microenvironment
- tumor prognosis
- immune checkpoint
- immune tolerance
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