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Gynecological Cancer: Targeted Therapeutics and Future Perspectives

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 3585

Special Issue Editor

Special Issue Information

Dear Colleagues,

It is well-known that gynecological cancers represent a real global public health problem. Moreover, their worldwide incidence and mortality rates are rising yearly, supporting the idea that therapeutical strategies and screening programs must be urgently revised and improved. This Special Issue aims to shed light on the recent advances in understanding the molecular background of gynecological cancer using significant genomic assays. The international guidelines promote a histomolecular approach to perform more accurate prognostic risk stratification and open the way to discovering and experimenting with more innovative targeted therapeutics. In this way,  the present research topic will provide a comprehensive review of the molecular alterations and the clinical evidence of ongoing and ended clinical trials on gynecological cancer and discuss the future implications of innovative molecular diagnostic and therapeutical approaches.

Since IJMS is a journal of molecular science, pure clinical studies will not suitable, but clinical submissions with biomolecular experiments are welcomed.

Dr. Angela Santoro
Guest Editor

Manuscript Submission Information

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Keywords

  •  molecular background
  •  precision medicine
  •  histomolecular diagnosis
  •  targeted therapies
  •  clinical trials
  •  overall survival
  •  disease-free survival
  •  gynecological cancer
  •  whole genomic assay
  •  molecular biomarkers

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Published Papers (1 paper)

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Review

23 pages, 3185 KiB  
Review
Mismatch Repair Deficiency as a Predictive and Prognostic Biomarker in Endometrial Cancer: A Review on Immunohistochemistry Staining Patterns and Clinical Implications
by Francesca Addante, Antonio d’Amati, Angela Santoro, Giuseppe Angelico, Frediano Inzani, Damiano Arciuolo, Antonio Travaglino, Antonio Raffone, Nicoletta D’Alessandris, Giulia Scaglione, Michele Valente, Giordana Tinnirello, Stefania Sfregola, Belen Padial Urtueta, Alessia Piermattei, Federica Cianfrini, Antonino Mulè, Emma Bragantini and Gian Franco Zannoni
Int. J. Mol. Sci. 2024, 25(2), 1056; https://doi.org/10.3390/ijms25021056 - 15 Jan 2024
Cited by 8 | Viewed by 3116
Abstract
Among the four endometrial cancer (EC) TCGA molecular groups, the MSI/hypermutated group represents an important percentage of tumors (30%), including different histotypes, and generally confers an intermediate prognosis for affected women, also providing new immunotherapeutic strategies. Immunohistochemistry for MMR proteins (MLH1, MSH2, MSH6 [...] Read more.
Among the four endometrial cancer (EC) TCGA molecular groups, the MSI/hypermutated group represents an important percentage of tumors (30%), including different histotypes, and generally confers an intermediate prognosis for affected women, also providing new immunotherapeutic strategies. Immunohistochemistry for MMR proteins (MLH1, MSH2, MSH6 and PMS2) has become the optimal diagnostic MSI surrogate worldwide. This review aims to provide state-of-the-art knowledge on MMR deficiency/MSI in EC and to clarify the pathological assessment, interpretation pitfalls and reporting of MMR status. Full article
(This article belongs to the Special Issue Gynecological Cancer: Targeted Therapeutics and Future Perspectives)
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