Interactions between the Environment and the Intestinal Epithelium: Gut Barrier Function and Inflammation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 17160
Special Issue Editors
Interests: intestinal barrier function; gut microbiota; mucosal immunology; inflammatory bowel disease; IBD pathways (Nod2, autophagy, endoplasmic reticulum stress, Th17)
Special Issues, Collections and Topics in MDPI journals
2. Unité de Gastroentérologie, Hépatologie, Nutrition, Diabétologie et Maladies Héréditaires du Métabolisme, Hôpital des Enfants, CHU de Toulouse, F-31300 Toulouse, France
Interests: inflammatory bowel disease; translational research; nutrition; cystic fibrosis; intestinal polyposis; endoscopy; gut microbiota
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The gastrointestinal tract is a complex interface between the immune system and its external environment. It establishes a dynamic barrier that enables dietary nutrients to be absorbed and harmful compounds to be excluded from the intestinal lumen, while permitting the sampling of luminal antigens as part of immune surveillance. The ability to control the intake of nutrients across the mucosa and protect it from damage of harmful substances contained in the lumen is defined as the intestinal barrier function (IBF). The IBF comprises epithelial cells, as well as immune cells and their secretions. Gut microbiota participate in regulating the integrity and function of the intestinal barrier by maintaining a homeostatic balance. Pathogens, xenobiotics and diet can disrupt the IBF, which causes tissue damage and systemic inflammation.
Numerous human diseases, including intestinal pathologies (inflammatory bowel diseases, irritable bowel syndrome, celiac disease, etc.), as well as extra-intestinal pathologies (metabolic, infectious, neurologic, and cardiovascular), are linked to an impairment of the IBF, leading to the development of “leaky gut syndrome”. Therefore, identifying and understanding the mechanisms by which environmental factors destabilize the IBF, thus promoting disease development, represent an important research direction for the diagnosis and treatment of various intestinal and extra-intestinal diseases.
Here, we invite experts to contribute to this Special Issue with original research or review articles, investigating the components of the environment that may have a beneficial or detrimental impact on the IBF. Since IJMS is a molecular sciences journal, purely clinical studies will not suitable. However, clinical or pure model submissions with biomolecular experiments are welcomed.
Dr. Frédérick Barreau
Prof. Dr. Emmanuel Mas
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- advances on the environmental factors including nano- and micro-particles and pesticides
- food additives
- microbiota metabolites with anti- or pro-inflammatory properties
- intestinal permeability
- intestinal stem cells
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
