Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.1
4.9
Journals
IJMS
Special Issues
Advanced Research on HIV Virus and Infection
ijms-logo
Submit to Special Issue Submit Abstract to Special Issue Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Advanced Research on HIV Virus and Infection

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 5301

Special Issue Editor

Dr. Patricia Price

E-Mail Website
Guest Editor
Faculty of Health Sciences, School of Pharmacy and Biomedical Sciences, Curtin University, Perth, Australia
Interests: CMV; NK cells; HCV; HIV; non tuberculous mycobacteria
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our Special Issue of the International Journal of Molecular Sciences (IJMS), titled “Advanced Research on HIV Virus and Infection” supervised by Dr. Patricia Price and assisted by our Topical Advisory Panel member, Dr. Shelley Waters.

While the replication of HIV, the depletion of CD4 T-cells, and the persistent activation of a patient’s immune system have been studied extensively, HIV disease remains incurable, and its management is critical to the well-being of many people worldwide. A factor that is often overlooked is that the rapid administration of antiretroviral therapies can now stop disease progression at an early stage. This creates a novel condition where CD4 T-cells remain, but the chronic immune activation is not averted. It is unclear how this affects the profile of co-infections, but it is likely that the characteristics of advanced HIV disease still have tremendous influence on antiretroviral therapies. The role of herpesviruses (notably, CMV) in the modification of the immune system is now emerging, and more research is warranted. The molecular aspects of co-infections prevalent in the developing world (e.g., tuberculosis) in this context remain unclear.

This Special Issue will address the state of the immune system in patients with specific outcomes achieved from HIV disease and antiretroviral therapies, as well as the immunological consequences of particular co-infections. We are sure that this collection will be a useful guide for scientists and clinicians. Data on molecular mechanisms or pathophysiology are essential, and papers that only contain clinical trials/data are not acceptable.

Dr. Patricia Price
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • HIV
  • viral proteins
  • immunogenetics
  • pathogenesis

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

13 pages, 3319 KiB  
Article
Anti-HIV Humoral Response Induced by Different Anti-Idiotype Antibody Formats: An In Silico and In Vivo Approach
by Valeria Caputo, Ilaria Negri, Louiza Moudoud, Martina Libera, Luigi Bonizzi, Massimo Clementi and Roberta Antonia Diotti
Int. J. Mol. Sci. 2024, 25(11), 5737; https://doi.org/10.3390/ijms25115737 - 24 May 2024
Viewed by 1114
Abstract
Despite advancements in vaccinology, there is currently no effective anti-HIV vaccine. One strategy under investigation is based on the identification of epitopes recognized by broadly neutralizing antibodies to include in vaccine preparation. Taking into account the benefits of anti-idiotype molecules and the diverse [...] Read more.
Despite advancements in vaccinology, there is currently no effective anti-HIV vaccine. One strategy under investigation is based on the identification of epitopes recognized by broadly neutralizing antibodies to include in vaccine preparation. Taking into account the benefits of anti-idiotype molecules and the diverse biological attributes of different antibody formats, our aim was to identify the most immunogenic antibody format. This format could serve as a foundational element for the development of an oligo-polyclonal anti-idiotype vaccine against HIV-1. For our investigation, we anchored our study on an established b12 anti-idiotype, referred to as P1, and proposed four distinct formats: two single chains and two minibodies, both in two different orientations. For a deeper characterization of these molecules, we used immunoinformatic tools and tested them on rabbits. Our studies have revealed that a particular minibody conformation, MbVHVL, emerges as the most promising candidate. It demonstrates a significant binding affinity with b12 and elicits a humoral anti-HIV-1 response in rabbits similar to the Fab format. This study marks the first instance where the minibody format has been shown to provoke a humoral response against a pathogen. Furthermore, this format presents biological advantages over the Fab format, including bivalency and being encoded by a monocistronic gene, making it better suited for the development of RNA-based vaccines. Full article
(This article belongs to the Special Issue Advanced Research on HIV Virus and Infection)
►▼ Show Figures

Figure 1

Review

Jump to: Research

14 pages, 631 KiB  
Review
Entangled Connections: HIV and HPV Interplay in Cervical Cancer—A Comprehensive Review
by Giuliana Pavone, Andrea Marino, Viviana Fisicaro, Lucia Motta, Alessandra Spata, Federica Martorana, Serena Spampinato, Benedetto Maurizio Celesia, Bruno Cacopardo, Paolo Vigneri and Giuseppe Nunnari
Int. J. Mol. Sci. 2024, 25(19), 10358; https://doi.org/10.3390/ijms251910358 - 26 Sep 2024
Cited by 2 | Viewed by 2200
Abstract
Cervical cancer (CC) remains a prevalent malignancy and a significant global public health concern, primarily driven by persistent human papillomavirus (HPV) infections. The infectious nature of HPV underscores the preventability of CC through vaccination and screening programs. In addition to HPV, factors such [...] Read more.
Cervical cancer (CC) remains a prevalent malignancy and a significant global public health concern, primarily driven by persistent human papillomavirus (HPV) infections. The infectious nature of HPV underscores the preventability of CC through vaccination and screening programs. In addition to HPV, factors such as age, parity, smoking, hormonal contraceptives, and HIV co-infection elevate the risk of CC. HIV-associated immunodeficiency exacerbates susceptibility to infections and cancers, making CC a defining condition for acquired immune deficiency syndrome (AIDS) and one of the most commonly diagnosed cancers among women living with HIV (WLWH). These women face higher risks of HPV exposure due to sexual behavior and often encounter economic, social, and psychological barriers to screening. HIV and HPV co-infection can potentially accelerate CC carcinogenesis, with WLWH typically being diagnosed with CC earlier than their HIV-negative counterparts. Antiretroviral therapy (ART), which reduces AIDS-related mortality, also lowers the risk of invasive CC. The interaction between HIV and HPV is intricate and bidirectional. This summary reviews current evidence on HPV infection and CC in WLWH, highlighting the connections across pathogenesis, prevention, diagnosis, and treatment. Full article
(This article belongs to the Special Issue Advanced Research on HIV Virus and Infection)
►▼ Show Figures

Figure 1

17 pages, 3486 KiB  
Review
Altered Host microRNAomics in HIV Infections: Therapeutic Potentials and Limitations
by Maria J. Santiago, Srinivasan Chinnapaiyan, Kingshuk Panda, Md. Sohanur Rahman, Suvankar Ghorai, Irfan Rahman, Stephen M. Black, Yuan Liu and Hoshang J. Unwalla
Int. J. Mol. Sci. 2024, 25(16), 8809; https://doi.org/10.3390/ijms25168809 - 13 Aug 2024
Viewed by 1316
Abstract
microRNAs have emerged as essential regulators of health and disease, attracting significant attention from researchers across diverse disciplines. Following their identification as noncoding oligonucleotides intricately involved in post-transcriptional regulation of protein expression, extensive efforts were devoted to elucidating and validating their roles in [...] Read more.
microRNAs have emerged as essential regulators of health and disease, attracting significant attention from researchers across diverse disciplines. Following their identification as noncoding oligonucleotides intricately involved in post-transcriptional regulation of protein expression, extensive efforts were devoted to elucidating and validating their roles in fundamental metabolic pathways and multiple pathologies. Viral infections are significant modifiers of the host microRNAome. Specifically, the Human Immunodeficiency Virus (HIV), which affects approximately 39 million people worldwide and has no definitive cure, was reported to induce significant changes in host cell miRNA profiles. Identifying and understanding the effects of the aberrant microRNAome holds potential for early detection and therapeutic designs. This review presents a comprehensive overview of the impact of HIV on host microRNAome. We aim to review the cause-and-effect relationship between the HIV-induced aberrant microRNAome that underscores miRNA’s therapeutic potential and acknowledge its limitations. Full article
(This article belongs to the Special Issue Advanced Research on HIV Virus and Infection)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop