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Synthesis and Molecular Research of Drugs for Skin Diseases and Cosmetic Ingredients

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 9846

Special Issue Editors


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Guest Editor
Department of the Chemistry of Cosmetic Raw Materials, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego Street 1, 90-151 Lodz, Poland
Interests: medicinal chemistry; metal ion complexes with flavonoid; coumarin and chromone derivatives as ligand; skin cancer

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Guest Editor
Department of the Chemistry of Cosmetic Raw Materials, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego Street 1, 90-151 Lodz, Poland
Interests: medicinal chemistry; synthesis of metal ion complexes of anticancer activity

Special Issue Information

Dear Colleagues,

Skin diseases, both benign and malignant, are considered a major health problem due to their high prevalence and psychological impact because of the visibility of skin lesions. Skin diseases can result from genetic predispositions, environmental factors, immune dysregulation, or a combination of these factors. By studying the molecular mechanisms involved in these diseases, researchers aim to unravel the intricate cellular processes contributing to their development, progression, and symptom manifestation.

Due to the fact that the most important function of the skin results from its protective properties in relation to physical, chemical, biological and mechanical stimuli, the search for drugs that would protect the patient against these problems is a challenge for 21st century medicine. Moreover, cancerous lesions in the skin are a serious problem. Exploring the mechanisms of etiopathogenesis may contribute to developing new and more effective therapeutic approaches for the prevention and treatment of skin cancer. Therefore, in this special issue of IJMS, we want to focus not only on the synthesis of oncological drugs against skin cancer, but also on drugs that modulate the intracellular activity of enzymes. We also want to propose research on improving skin parameters after various types of cosmetic and cosmetological treatments.

We invited all colleagues to our special issue of IJMS, in which we will publish the latest information on progress in research on skin diseases taking into account their molecular action. We invite chemists involved in the synthesis of new dermatological drugs, as well as those working on the molecular mechanisms of their action, to cooperate with us. We invite teams related to the field of dermatology to submit articles presenting both research and review works on molecular mechanisms related to skin diseases, including therapy and prevention. In this special issue, we aim to present research progress on all types of skin diseases, whether inflammatory, cancerous or infectious.

Prof. Dr. Elzbieta Budzisz
Dr. Paulina Mucha
Guest Editors

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Keywords

  • skin diseases
  • skin cancers
  • aging
  • pathogenesis
  • topical dermatological therapy
  • systemic dermatological therapy
  • cosmetic ingredients
  • molecular mechanism
  • drugs design and synthesis
  • molecular mechanism

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Published Papers (4 papers)

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Research

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21 pages, 4311 KiB  
Article
Biologically Active Sheep Colostrum for Topical Treatment and Skin Care
by Kinga Kazimierska, Ilona Szabłowska-Gadomska, Stefan Rudziński, Katarzyna Kośla, Elżbieta Płuciennik, Łukasz Bobak, Aleksandra Zambrowicz and Urszula Kalinowska-Lis
Int. J. Mol. Sci. 2024, 25(15), 8091; https://doi.org/10.3390/ijms25158091 - 25 Jul 2024
Cited by 1 | Viewed by 1424
Abstract
Colostrum is gaining popularity in cosmetic products. The present study compared the composition and selected biological properties of colostrum from Polish sheep (colostrum 1) and Swiss sheep (colostrum 2), particularly those that can affect healthy or diseased skin. The antioxidant activity of the [...] Read more.
Colostrum is gaining popularity in cosmetic products. The present study compared the composition and selected biological properties of colostrum from Polish sheep (colostrum 1) and Swiss sheep (colostrum 2), particularly those that can affect healthy or diseased skin. The antioxidant activity of the colostrums was measured using ABTS and DPPH assays. The effect on the proliferation of human skin fibroblasts, neonatal epidermal keratinocytes, and human diabetic fibroblast (dHF) cells isolated from diabetic foot ulcers was also assayed in vitro by MTT and Presto Blue tests, respectively. The colostrum simulated dHF cell proliferation by up to 115.4%. The highest used concentration of colostrum 1 stimulated normal fibroblast proliferation by 191.2% (24 h) and 222.2% (48 h). Both colostrums inhibited epidermal keratinocyte viability. The influence of the colostrums on the expression of genes related to proliferation (Ki67) and immune response (IL-6, PTGS-2, TSG-6) in dHF cells were compared. Colostrum 1 increased the rate of wound closure (scar test). Analysis of total fat, protein and fatty acid content found the Polish colostrum to be a richer source of fat than the Swiss colostrum, which contained a larger amount of protein. Both colostrums exhibit properties that suggest they could be effective components in cosmetic or medicinal formulations for skin care, especially supporting its regeneration, rejuvenation, and wound healing. Full article
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Review

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18 pages, 939 KiB  
Review
Targeting Matrix Metalloproteinases and Their Inhibitors in Melanoma
by Orest Szczygielski, Emilia Dąbrowska, Sylwia Niemyjska, Andrzej Przylipiak and Monika Zajkowska
Int. J. Mol. Sci. 2024, 25(24), 13558; https://doi.org/10.3390/ijms252413558 - 18 Dec 2024
Viewed by 627
Abstract
Malignant melanoma is one of the most important dermatological neoplasms. The high mortality rate associated with this skin disease is primarily due to the occurrence of metastases, while the diagnosis and treatment of melanoma in its early stages has a favorable prognosis. Early [...] Read more.
Malignant melanoma is one of the most important dermatological neoplasms. The high mortality rate associated with this skin disease is primarily due to the occurrence of metastases, while the diagnosis and treatment of melanoma in its early stages has a favorable prognosis. Early detection is crucial because the success of treatment is directly related to the depth of cancerous growth. The family of matrix metalloproteinases (MMPs) plays a critical role in the initiation and progression of melanoma. Prominent MMPs, including MMP-1, MMP-2, MMP-3, MMP-9, MMP-13, and MMP-14, have been shown to significantly contribute to the development of melanoma. The tumor microenvironment, particularly the extracellular matrix (ECM), has emerged as a critical factor in modulating cancer progression. This review focuses on the role of matrix metalloproteinases and their inhibitors in ECM degradation and the subsequent progression of melanoma, as well as their potential as therapeutic targets. Full article
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10 pages, 593 KiB  
Review
A Novel Look at Mechanisms and Applications of Xanthohumol (XN) in Dermatology and Cosmetology
by Anna Kołodziejczak, Marta Dziedzic, Barbara Algiert-Zielińska, Paulina Mucha and Helena Rotsztejn
Int. J. Mol. Sci. 2024, 25(22), 11938; https://doi.org/10.3390/ijms252211938 - 6 Nov 2024
Viewed by 1169
Abstract
Xanthohumol (XN), representing the group of chalcones, is a hydroxyl and superoxide free radical scavenger. It also has antimicrobial properties, showing antibacterial activity against Staphylococcus aureus, Staphylococcus pyogenes, Staphylococcus epidermidis and Propionibacterium acnes. XN exerts an inhibitory effect on tyrosinase (it hinders the [...] Read more.
Xanthohumol (XN), representing the group of chalcones, is a hydroxyl and superoxide free radical scavenger. It also has antimicrobial properties, showing antibacterial activity against Staphylococcus aureus, Staphylococcus pyogenes, Staphylococcus epidermidis and Propionibacterium acnes. XN exerts an inhibitory effect on tyrosinase (it hinders the oxidation of l-tyrosine and l-DOPA). However, it also affects the transport of pigment (through a reduction in the number and length of dendrites) and its degradation (through damage to melanosomes). Additionally, it has been shown to inhibit the different activation pathways of the premeditated response in macrophages and reduce the secretion of pro-inflammatory cytokines TNF-α, IL-6 and IL-1β. Xanthohumol also improves skin elasticity by reducing the activity of elastase and MMP 1, 2 and 9, and it increases the expression of type I, III and V collagen, as well as elastin and fibrillins in skin fibroblasts. It acts against the main factors contributing to the pathogenesis of acne by inhibiting pro-inflammatory mediators (e.g., COX-2, PGE2, IL-1β and TNF-α). Moreover, it shows antibacterial activity against P. acnes and S. aureus, as well as seboregulatory and antioxidant properties. It has also been recognized that XN intake could affect diabetic wound healing. XN shows antitumoral activity, e.g., in the case of skin melanoma, which is associated with the antioxidant, pro-apoptotic, anti-angiogenic and immunostimulating effects of this compound. Full article
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19 pages, 1548 KiB  
Review
Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness
by Kar Wai Alvin Lee, Kwin Wah Lisa Chan, Angela Lee, Cheuk Hung Lee, Jovian Wan, Sky Wong and Kyu-Ho Yi
Int. J. Mol. Sci. 2024, 25(15), 8224; https://doi.org/10.3390/ijms25158224 - 27 Jul 2024
Cited by 2 | Viewed by 6054
Abstract
Polynucleotides, complex molecules composed of nucleotides, have gained attention in aesthetic medicine for their potential to regulate gene expression and promote tissue regeneration. This review aims to provide an overview of the current practices and perceived effectiveness of polynucleotides in aesthetic medicine. A [...] Read more.
Polynucleotides, complex molecules composed of nucleotides, have gained attention in aesthetic medicine for their potential to regulate gene expression and promote tissue regeneration. This review aims to provide an overview of the current practices and perceived effectiveness of polynucleotides in aesthetic medicine. A comprehensive search of the literature was conducted using keywords related to polynucleotides, cosmetic application, and aesthetic application. Studies were selected based on their relevance to aesthetic medicine and the inclusion of human subjects. The review found that polynucleotides have been used to improve skin texture, reduce wrinkle depth, and enhance facial appearance. The studies reported varying degrees of efficacy and safety, with some studies demonstrating significant improvements in skin elasticity and hydration. However, others reported limited or no benefits. The review also highlighted the need for further research to establish the optimal use and efficacy of polynucleotides in aesthetic medicine. While the existing literature suggests that polynucleotides may have potential benefits in aesthetic medicine, more research is needed to fully understand their mechanisms of action and optimal use. Clinicians should be aware of the current limitations and potential risks associated with the use of polynucleotides in aesthetic medicine. Full article
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