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Musculoskeletal Disorders: From Molecular Pathology to Novel Therapeutic Approach

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 1299

Special Issue Editor


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Guest Editor
Unidad de Investigación en Fisioterapia, Facultad de Ciencias de la Salud, Universidad de Zaragoza, Domingo Miral, s/n, 50009 Zaragoza, Spain
Interests: physiotherapy; musculoskeletal disorders; dry needling; manual therapy; instrumentally assisted manual therapy; therapeutic exercise

Special Issue Information

Dear Colleagues,

Musculoskeletal disorders are one of the most prevalent pathologies worldwide and may affect a diversity of tisular organizations conforming to the structural components of the neuromusculoskeletal system. The high prevalence of these pathologies, particularly of those with a chronic nature, seems to be on the rise, raising concerns regarding the older average age of the population and certain lifestyle habits, such as a sedentary lifestyle, which determine a physiological state that is prone to the appearance and chronicity of this type of pathology. A sedentary lifestyle leads to a destabilization of cellular homeostasis, which is linked to major macroscopic dysfunctions, such as obesity, but also to imbalances in tissue functioning that can favor the chronicity of musculoskeletal disorders.

This will be lead by Prof. Dr. María Orosia Lucha-López and assisted by our Topical Advisory Panel Member Dr. Clemens Gögele (Paracelsus Medical University). This Special Issue of IJMS, entitled “Musculoskeletal Disorders: From Molecular Pathology to Novel Therapeutic Approach”, aims to consolidate research highlighting new insights in the pathological mechanisms behind the regenerative failure of musculoskeletal system tissues. In addition, new evidence based on novel therapeutic approaches in which action mechanisms might be clearer today, thanks to novel discoveries in pathological mechanisms, will enrich the future treatment of musculoskeletal disorders.

Prof. Dr. María Orosia Lucha López
Guest Editor

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Keywords

  • joints
  • skeletal muscles
  • tendons
  • ligaments
  • fascia
  • articular cartilage
  • intervertebral discs
  • physiotherapy
  • novel therapies

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Published Papers (1 paper)

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Review

15 pages, 1822 KiB  
Review
Association between Estrogen Levels and Temporomandibular Disorders: An Updated Systematic Review
by Grzegorz Zieliński and Beata Pająk-Zielińska
Int. J. Mol. Sci. 2024, 25(18), 9867; https://doi.org/10.3390/ijms25189867 - 12 Sep 2024
Cited by 1 | Viewed by 1065
Abstract
The aim of this systematic review is to evaluate the impact of estrogen levels on the occurrence of temporomandibular disorders (TMDs) in humans. Searches were conducted in the same databases as follows: PubMed, the Cochrane Collaboration database, and the Scopus database. In accordance [...] Read more.
The aim of this systematic review is to evaluate the impact of estrogen levels on the occurrence of temporomandibular disorders (TMDs) in humans. Searches were conducted in the same databases as follows: PubMed, the Cochrane Collaboration database, and the Scopus database. In accordance with the MeSH database and previous work, the following keywords were used: ‘estrogens’ and ‘temporomandibular joint disorders’. Twelve studies were included in the review and were assessed for the quality of evidence. Estrogen levels are associated with pain modulation in the temporomandibular joint and the entire orofacial region. There is insufficient evidence to either confirm or refute the influence of estrogen on the occurrence of TMDs. The study was registered under the identifier: 10.17605/OSF.IO/BC7QF. Full article
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