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Advanced Research on Chemokines and Chemokine Receptors
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Advanced Research on Chemokines and Chemokine Receptors

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 5431

Special Issue Editor

Dr. Bouchra Edderkaoui

E-Mail Website
Guest Editor
1. Musculoskeletal Disease Center, Research Service, VA Loma Linda Healthcare Systems, Loma Linda, CA 92357, USA
2. Department of Medicine, Loma Linda University, Loma Linda, CA 92354, USA
Interests: chemokines; chemokine receptors; inflammation; regeneration; inhibitors; stimulators; molecular signaling pathways

Special Issue Information

Dear Colleagues,

Chemokines belong to a family of small cytokines; they promote the directional migration of leukocytes, endothelial and epithelial cells through binding to their specific receptors. They share a typical key structure that is stabilized by disulfide bonds between the cysteine residues at the NH2-terminal of the protein. Chemokines are secreted by a great variety of cells. Their function is directly dependent on their interactions with their receptors. They are involved in many physiological processes, including but not limited to embryogenesis, bone remodeling, fracture healing and wound healing. They play a vital role in host defense mechanisms through the development and maintenance of innate and acquired immunity, but their chronic expression is linked with chronic diseases, delayed fracture and wound healing, and other health complications.

In this Special Issue entitled Advanced Research on Chemokines and Chemokine Receptors, we invite scientists to submit review articles and original research articles about the latest discoveries which further our understanding of the function and role of chemokines and their receptors in different physiological and pathological processes, and about studies which explore strategies for the development of new molecules or drugs to modulate chemokines’ functions.

Dr. Bouchra Edderkaoui
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chemokines
  • chemokine receptors
  • chronic diseases
  • angiogenesis
  • fracture
  • regeneration
  • chemokine function
  • expression

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Published Papers (3 papers)

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Research

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15 pages, 3131 KiB  
Article
CXCL14 as a Key Regulator of Neuronal Development: Insights from Its Receptor and Multi-Omics Analysis
by Yinjie Zhang, Yue Jin, Jingjing Li, Yan Yan, Ting Wang, Xuanlin Wang, Zhenyu Li and Xuemei Qin
Int. J. Mol. Sci. 2024, 25(3), 1651; https://doi.org/10.3390/ijms25031651 - 29 Jan 2024
Cited by 3 | Viewed by 1476
Abstract
CXCL14 is not only involved in the immune process but is also closely related to neurodevelopment according to its molecular evolution. However, what role it plays in neurodevelopment remains unclear. In the present research, we found that, by crossbreeding CXCL14+/− and CXCL14 [...] Read more.
CXCL14 is not only involved in the immune process but is also closely related to neurodevelopment according to its molecular evolution. However, what role it plays in neurodevelopment remains unclear. In the present research, we found that, by crossbreeding CXCL14+/− and CXCL14−/− mice, the number of CXCL14−/− mice in their offspring was lower than the Mendelian frequency; CXCL14−/− mice had significantly fewer neurons in the external pyramidal layer of cortex than CXCL14+/− mice; and CXCL14 may be involved in synaptic plasticity, neuron projection, and chemical synaptic transmission based on analysis of human clinical transcriptome data. The expression of CXCL14 was highest at day 14.5 in the embryonic phase and after birth in the mRNA and protein levels. Therefore, we hypothesized that CXCL14 promotes the development of neurons in the somatic layer of the pyramidal cells of mice cortex on embryonic day 14.5. In order to further explore its mechanism, CXCR4 and CXCR7 were suggested as receptors by Membrane-Anchored Ligand and Receptor Yeast Two-Hybrid technology. Through metabolomic techniques, we inferred that CXCL14 promotes the development of neurons by regulating fatty acid anabolism and glycerophospholipid anabolism. Full article
(This article belongs to the Special Issue Advanced Research on Chemokines and Chemokine Receptors)
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21 pages, 8414 KiB  
Article
Fractalkine Improves the Expression of Endometrium Receptivity-Related Genes and Proteins at Desferrioxamine-Induced Iron Deficiency in HEC-1A Cells
by Edina Pandur, Ramóna Pap, Gergely Jánosa, Adrienn Horváth and Katalin Sipos
Int. J. Mol. Sci. 2023, 24(9), 7924; https://doi.org/10.3390/ijms24097924 - 27 Apr 2023
Cited by 5 | Viewed by 2030
Abstract
Fractalkine (CX3CL1/FKN) is a unique chemokine belonging to the CX3C chemokine subclass. FKN exists in two forms: a membrane-bound form expressed by both endometrium cells and trophoblasts thought to be implicated in maternal–fetal interaction and a soluble form expressed by endometrium cells. Endometrium [...] Read more.
Fractalkine (CX3CL1/FKN) is a unique chemokine belonging to the CX3C chemokine subclass. FKN exists in two forms: a membrane-bound form expressed by both endometrium cells and trophoblasts thought to be implicated in maternal–fetal interaction and a soluble form expressed by endometrium cells. Endometrium receptivity is crucial in embryo implantation and a complex process regulated by large numbers of proteins, e.g., cytokines, progesterone receptor (PR), SOX-17, prostaglandin receptors (PTGER2), and tissue inhibitors of metalloproteinases (TIMPs). It has also been reported that iron is important in fertility and affects the iron status of the mother. Therefore, iron availability in the embryo contributes to fertilization and pregnancy. In this study, we focused on the effect of iron deficiency on the secreted cytokines (IL-6, IL-1β, leukocyte inhibitory factor, TGF-β), chemokines (IL-8, FKN), and other regulatory proteins (bone morphogenic protein 2, activin, follistatin, PR, SOX-17, prostaglandin E2 receptor, TIMP2), and the modifying effect of FKN on the expression of these proteins, which may improve endometrium receptivity. Endometrial iron deficiency was mediated by desferrioxamine (DFO) treatment of HEC-1A cells. FKN was added to the cells 24 h and 48 h after DFO with or without serum for modelling the possible iron dependence of the alterations. Our findings support the hypothesis that FKN ameliorates the effects of anemia on the receptivity-related genes and proteins in HEC-1A cells by increasing the secretion of the receptivity-related cytokines via the fractalkine receptor (CX3CR1). FKN may contribute to cell proliferation and differentiation by regulating activin, follistatin, and BMP2 expressions, and to implantation by altering the protein levels of PR, SOX-17, PTGER2, and TIMP2. FKN mitigates the negative effect of iron deficiency on the receptivity-related genes and proteins of HEC-1A endometrium cells, suggesting its important role in the regulation of endometrium receptivity. Full article
(This article belongs to the Special Issue Advanced Research on Chemokines and Chemokine Receptors)
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Review

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16 pages, 779 KiB  
Review
Chemokines in Cartilage Regeneration and Degradation: New Insights
by Bouchra Edderkaoui
Int. J. Mol. Sci. 2024, 25(1), 381; https://doi.org/10.3390/ijms25010381 - 27 Dec 2023
Cited by 4 | Viewed by 1116
Abstract
Cartilage plays a crucial role in the human body by forming long bones during development and growth to bear loads on joints and intervertebral discs. However, the increasing prevalence of cartilage degenerative disorders is a growing public health concern, especially due to the [...] Read more.
Cartilage plays a crucial role in the human body by forming long bones during development and growth to bear loads on joints and intervertebral discs. However, the increasing prevalence of cartilage degenerative disorders is a growing public health concern, especially due to the poor innate regenerative capacity of cartilage. Chondrocytes are a source of several inflammatory mediators that play vital roles in the pathogenesis of cartilage disorders. Among these mediators, chemokines have been explored as potential contributors to cartilage degeneration and regeneration. Our review focuses on the progress made during the last ten years in identifying the regulators and roles of chemokines and their receptors in different mechanisms related to chondrocytes and cartilage. Recent findings have demonstrated that chemokines influence cartilage both positively and negatively. Their induction and involvement in either process depends on the local molecular environment and is both site- and time-dependent. One of the challenges in defining the role of chemokines in cartilage pathology or regeneration is the apparent redundancy in the interaction of chemokines with their receptors. Hence, it is crucial to determine, for each situation, whether targeting specific chemokines or their receptors will help in developing effective therapeutic strategies for cartilage repair. Full article
(This article belongs to the Special Issue Advanced Research on Chemokines and Chemokine Receptors)
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