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Genetics and Molecular Mechanisms in Psychological and Neuropsychiatric Disorders

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 4023

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Special Issue Information

Dear Colleagues,

In the last decade, the exponential increase in genetic studies has significantly advanced the knowledge of both psychological and neuropsychiatric brain pathologies. Recent research has demonstrated the prevalence of Alzheimer's disease, Parkinson's disease, epilepsy, mood disorders, etc. in different populations and/or in relation to sex. Interestingly, many researchers are turning their attention to the molecular implications of genetic modification. This Special Issue welcomes the submission of original research papers or comprehensive reviews that demonstrate or summarize significant advances in the field of genetics in the pathogenesis of psychological, neurological and psychiatric disorders. Basic research studies and/or clinical studies accompanied by experimental data will be considered.

Prof. Dr. Elisabetta Albi
Guest Editor

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Keywords

  • psychological disorder
  • neurological disorders
  • psychiatric disorders
  • genetics lipids

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Published Papers (1 paper)

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Review

16 pages, 4779 KiB  
Review
Genetic Update and Treatment for Dystonia
by Jan Koptielow, Emilia Szyłak, Olga Szewczyk-Roszczenko, Piotr Roszczenko, Jan Kochanowicz, Alina Kułakowska and Monika Chorąży
Int. J. Mol. Sci. 2024, 25(7), 3571; https://doi.org/10.3390/ijms25073571 - 22 Mar 2024
Cited by 2 | Viewed by 3583
Abstract
A neurological condition called dystonia results in abnormal, uncontrollable postures or movements because of sporadic or continuous muscular spasms. Several varieties of dystonia can impact people of all ages, leading to severe impairment and a decreased standard of living. The discovery of genes [...] Read more.
A neurological condition called dystonia results in abnormal, uncontrollable postures or movements because of sporadic or continuous muscular spasms. Several varieties of dystonia can impact people of all ages, leading to severe impairment and a decreased standard of living. The discovery of genes causing variations of single or mixed dystonia has improved our understanding of the disease’s etiology. Genetic dystonias are linked to several genes, including pathogenic variations of VPS16, TOR1A, THAP1, GNAL, and ANO3. Diagnosis of dystonia is primarily based on clinical symptoms, which can be challenging due to overlapping symptoms with other neurological conditions, such as Parkinson’s disease. This review aims to summarize recent advances in the genetic origins and management of focal dystonia. Full article
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