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Mitochondrial Metabolism Alterations in Health and Disease: 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 20 April 2025 | Viewed by 679

Special Issue Editors


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Guest Editor
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy
Interests: mitochondrial transporters; bioenergetics; mitochondrial diseases; cancers metabolism
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy
Interests: bioenergetics; mitochondrial carriers; mutagenesis; drosophila melanogaster; mitochondrial diseases; mitochondrial dysfunction; apoptosis; ROS; antioxidant and anti-inflammatory activity; cancer metabolism; anticancer agents
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy
Interests: ketogenic diet; microRNAs signature; catalase; heavy metals metabolic effects; epigenetics; apoptosis; antioxidant effects
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Mitochondria are key organelles responsible for cell energy production and are essential for eukaryotic life. They take part in critical metabolic pathways and are fully integrated into intracellular signaling networks, cellular differentiation, and apoptosis. Mitochondrial functions extend beyond cell boundaries and influence the organisms’ physiology by regulating the communication between cells and tissues. Mitochondria are involved in inherited mitochondrial disorders, neurodegenerative diseases, dystrophies, heart failure, cardiac dysfunction, vascular diseases and atherosclerosis, pulmonary and respiratory disorders, renal diseases, metabolic disorders, diabetes, aging, and cancer. Therefore, they are attracting increasing attention with the aim of fully understanding the link between the mitochondrial metabolism and the dysregulation of many cellular processes. This Special Issue will focus on mitochondrial metabolic alterations underlying various pathologies. Original manuscripts and reviews with a particular focus on the physiological role of mitochondria in cell life, as well as their involvement in human diseases assessed in cell lines, animal models, and/or patients, are welcome.

Prof. Dr. Vincenza Dolce
Dr. Rosita Curcio
Dr. Graziantonio Lauria
Guest Editors

Manuscript Submission Information

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Keywords

  • mitochondrial Metabolism
  • mitochondrial disorders
  • cellular processes
  • dysregulation organisms’ physiology

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Published Papers (1 paper)

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Review

19 pages, 1436 KiB  
Review
Exploring the Link Between Telomeres and Mitochondria: Mechanisms and Implications in Different Cell Types
by Graziana Assalve, Paola Lunetti, Maria Santa Rocca, Ilaria Cosci, Andrea Di Nisio, Alberto Ferlin, Vincenzo Zara and Alessandra Ferramosca
Int. J. Mol. Sci. 2025, 26(3), 993; https://doi.org/10.3390/ijms26030993 - 24 Jan 2025
Viewed by 517
Abstract
Telomeres protect chromosome ends from damage, but they shorten with each cell division due to the limitations of DNA replication and are further affected by oxidative stress. This shortening is a key feature of aging, and telomerase, an enzyme that extends telomeres, helps [...] Read more.
Telomeres protect chromosome ends from damage, but they shorten with each cell division due to the limitations of DNA replication and are further affected by oxidative stress. This shortening is a key feature of aging, and telomerase, an enzyme that extends telomeres, helps mitigate this process. Aging is also associated with mitochondrial dysfunction, leading to increased reactive oxygen species (ROS) that exacerbate cellular damage and promote apoptosis. Elevated ROS levels can damage telomeres by oxidizing guanine and disrupting their regulation. Conversely, telomere damage impacts mitochondrial function, and activation of telomerase has been shown to reverse this decline. A critical link between telomere shortening and mitochondrial dysfunction is the DNA damage response, which activates the tumor suppressor protein p53, resulting in reduced mitochondrial biogenesis and metabolic disruptions. This highlights the bidirectional relationship between telomere maintenance and mitochondrial function. This review explores the complex interactions between telomeres and mitochondria across various cell types, from fibroblasts to sperm cells, shedding light on the interconnected mechanisms underlying aging and cellular function. Full article
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