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Research on Application of Nanomaterials in Drug Delivery

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 3255

Special Issue Editors


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Guest Editor
Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, Poland
Interests: lipid nanoparticles; drug delivery and targeting; nanotoxicology and nanosafety; pharmaceutical chemistry; cosmetics; nanomedicine; clinical trials
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Department of Drug and Health Sciences, University of Catania, Catania, Italy
2. NANOMED-Research Centre on Nanomedicine and Pharmaceutical Nanotechnology, University of Catania, Catania, Italy
Interests: drug delivery; nanomedicine; nutraceuticals; pharmaceutical technology; natural compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the past decades, the demand for nanotechnology has been increasing, and the application of nanomaterials has become more and more extensive. Nanomaterials have been applied in biomedical as drug delivery, tissue engineering, and diagnostics for disease. In particular, the application of nanotechnology for drug delivery offers the advantage of a promising potential strategy for enhanced treatments with targeted delivery and fewer side effects. Nanotechnology drug delivery applications occur through the use of designed nanomaterials and forming delivery systems in the nanoscale range including both vesicles, such as liposomes, and particles of different nature, namely polymeric, lipid, hybrid, or organic.

Nanomaterials’ application in drug delivery systems can provide different advantages, such as drug protection, improving drug bioavailability, modifying drug distribution with targeting activity, and controlling drug release concerning the specific different routes or treatment disease (ophthalmic administration, cancer treatment, brain diseases or more specific disease such as coronary artery disease).

Therefore, the purpose of this research topic is to collect original research articles and review papers that present an overview of current trends and applications of different nanomaterials (polymers, lipids, surfactants, active drugs) by investigating their effect on the final characteristics of the nano-drug delivery system. Particular attention will be paid to the safety of raw nanomaterials and the developed nanosystem, discussed about the target site and application in human medicine.

Dr. Aleksandra Zielinska
Prof. Dr. Claudia Carbone
Guest Editors

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Keywords

  • nanomaterials
  • nanoparticles
  • vesicles
  • drug delivery
  • tissue engineering
  • human medicine

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Published Papers (1 paper)

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Research

17 pages, 5961 KiB  
Article
PEGylated Liposomes Loaded with Carbamate Inhibitor ANP0903 Trigger Apoptosis by Enhancing ER Stress in HepG2 Cancer Cells
by Carla Caddeo, Rocchina Miglionico, Roberta Rinaldi, Ilaria Nigro, Daniela Lamorte, Lucia Chiummiento, Paolo Lupattelli, Maria Funicello, Rosarita D’Orsi, Donatella Valenti, Valentina Santoro, Anna Maria Fadda, Faustino Bisaccia, Antonio Vassallo and Maria Francesca Armentano
Int. J. Mol. Sci. 2023, 24(5), 4552; https://doi.org/10.3390/ijms24054552 - 25 Feb 2023
Cited by 4 | Viewed by 2493
Abstract
Liver cancer is one of the most common causes of cancer death worldwide. In recent years, substantial progress has been made in the development of systemic therapies, but there is still the need for new drugs and technologies that can increase the survival [...] Read more.
Liver cancer is one of the most common causes of cancer death worldwide. In recent years, substantial progress has been made in the development of systemic therapies, but there is still the need for new drugs and technologies that can increase the survival and quality of life of patients. The present investigation reports the development of a liposomal formulation of a carbamate molecule, reported as ANP0903, previously tested as an inhibitor of HIV-1 protease and now evaluated for its ability to induce cytotoxicity in hepatocellular carcinoma cell lines. PEGylated liposomes were prepared and characterized. Small, oligolamellar vesicles were produced, as demonstrated by light scattering results and TEM images. The physical stability of the vesicles in biological fluids was demonstrated in vitro, alongside the stability during storage. An enhanced cellular uptake was verified in HepG2 cells treated with liposomal ANP0903, resulting in a greater cytotoxicity. Several biological assays were performed to elucidate the molecular mechanisms explaining the proapoptotic effect of ANP0903. Our results allow us to hypothesize that the cytotoxic action in tumor cells is probably due to the inhibition of the proteasome, resulting in an increase in the amount of ubiquitinated proteins within the cells, which in turn triggers activation of autophagy and apoptosis processes, resulting in cell death. The proposed liposomal formulation represents a promising approach to deliver a novel antitumor agent to cancer cells and enhance its activity. Full article
(This article belongs to the Special Issue Research on Application of Nanomaterials in Drug Delivery)
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